With Kane sidelined, Son Heung-Min at the Asian Cup and Lucas Moura "90 percent out" Spurs are in a striker bind ahead of their match with Fulham.
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Mauricio Pochettino has vowed not to "cry" as injuries and departures mount within his squad.
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Mousa Dembele has completed his move to Chinese Super League club Guangzhou R&F, with sources telling ESPN FC that Tottenham have banked £9m.
Kane damaged left ankle ligaments near the end of the 1-0 loss to Manchester United at Wembley on Sunday after being sandwiched between defenders.
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Mousa Dembele never fit categorization during his time in the Premier League and his unique skill set might never be seen again.
Harry Kane limped off the field following Spurs' 1-0 defeat to Manchester United at Wembley.
Ole Gunnar Solskjaer is perfect so far at Man United but he hasn't just done it by lifting their spirits. Against Spurs, he showed his intelligence.
Kane and Son's absences will be felt hard by Tottenham unless reinforcements arrive. But Pochettino could be the next to depart if they aren't.
A Tottenham fan tweeted that he felt compelled to confront another member of the home crowd after being disgusted by what he heard.
It's not just Spurs who'll miss Son Heung-Min while he's at the Asian Cup. Here's why the whole Premier League will be worse off for without him.
"We are going to lose Son [Heung-Min] for the Asia Cup and if Harry Kane suffers an injury, it is going to be massive for us," Pochettino said.
Man United have won games before under their caretaker manager, but the victory at Spurs showed why Ole Gunnar Solskjaer's reputation is growing.
Solskjaer saw his odds on becoming Jose Mourinho's long-term successor cut after the 1-0 win at Wembley on Sunday.
Tottenham paid for their profligacy as they suffered a 1-0 home defeat to Manchester United on Sunday.
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