The 18-year-old Hudson-Odoi was set to join the Under-21 squad in Bristol when he was told he had received his first senior call-up.
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Tottenham have had some tough results of late but defeat at Southampton, with Kane, Alli and Eriksen all in the lineup, should cause panic.
Late goals from Yan Valery and James Ward-Prowse saw Southampton come from behind to earn a 2-1 win over Tottenham.
Romelu Lukaku scored two for Manchester United, including one in the 88th minute, to earn a 3-2 victory over Southampton.
Southampton moved out of the relegation zone with a crucial 2-0 home win against struggling Fulham on Wednesday.
Arsenal moved ahead of Manchester United and back into the top four with a 2-0 win against Southampton.
Southampton said it will investigate an incident where two fans made gestures toward Cardiff City supporters allegedly mocking Emiliano Sala.
Cardiff City's Kenneth Zohore struck deep into stoppage time to secure a crucial 2-1 win on Saturday away to fellow strugglers Southampton.
Burnley converted a stoppage time penalty through Ashley Barnes to earned a 1-1 draw with Southampton at Turf Moor on Saturday.
|West Ham United||31||12||6||13||-5||42|
|Brighton & Hove Albion||29||9||6||14||-10||33|