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Eden Hazard marked his 100th cap with an early goal to set Belgium on their way to a comfortable 2-0 away win over Cyprus.
Lukaku sat out United's FA Cup defeat at Wolves last weekend and also missed Belgium's qualifying win over Russia on Thursday.
Thibaut Courtois was at fault for Russia's goal as Belgium won 3-1 in their Euro 2020 qualifier.
Eden Hazard scored twice for Belgium to spare the blushes of goalkeeper Thibaut Courtois and secure a 3-1 victory over Russia.
The 31-year-old scored 18 goals in 87 appearances for Belgium and represented them at two World Cups, helping them finish third in Russia last year.
Belgium will end 2018 at No. 1 in the FIFA World rankings, with World Cup winners France at No. 2 and Brazil at No. 3.
Radja Nainggolan has told ESPN FC he won't play for Belgium again and has hit out at the "pathetic" excuses behind his international exile.
The next World Cup is four years away, but if it began today, how would the major nations line up? We asked our writers to look into the future.
Gareth Southgate's impact was evident again, though his praise of Harry Kane possibly went a bit far. Plus: What went wrong for Belgium and France?
Some players felt the World Cup semifinalists might have got carried away after they went two goals ahead after only 17 minutes.
Haris Seferovic scored a hat trick as Switzerland recovered from conceding two early goals to beat World Cup semifinalists Belgium 5-2 on Sunday.
The hosts, number one in FIFA's world rankings, were missing several players due to injury, with striker Romelu Lukaku ruled out a day before.
Marouane Fellaini's afro was one of the few constants in this ever-changing world, but the Manchester United man has got rid of his famous fuzzy do.
Romelu Lukaku has missed the last two games for Manchester United, while Eden Hazard has also been struggling for fitness at Chelsea.
Real Madrid are yet to make an official approach for Roberto Martinez, a spokesperson for the Belgian Football Association has told ESPN FC.
Thorgan Hazard has said that it would be 'difficult' to play in the same team as older brother Eden.
Belgium have edged ahead of France to take outright top spot in FIFA's world rankings released on Thursday, while Gibraltar were the biggest risers.
Netherlands forward Arnaut Groeneveld scored his first international goal to secure a 1-1 draw at neighbours Belgium in a friendly on Tuesday.
The father of Manchester City captain Vincent Kompany was elected as the first black mayor in Belgium after winning support in a Brussels commune.
Romelu Lukaku scored twice to earn Belgium a 2-1 victory over Switzerland in the Nations League on Friday.
Belgian authorities have arrested nine people in relation to a massive financial fraud and match-fixing probe into soccer.