Garland suffered the injury early in the Commodores' game against Kent State on Friday.
"Darius had a very successful surgery, and will be better than ever when he returns," Drew said in a statement. "Unfortunately, he will be out for the remainder of this season."
A 6-foot-2 native of Nashville, Tennessee, Garland was the No. 1 point guard in the 2018 high school class and is a projected lottery pick in the 2019 NBA draft. He is averaging 16.2 points, 3.8 rebounds and 2.6 assists per game while shooting 47.8 percent from 3-point range. He scored 33 points during last week's win over Liberty.
ESPN's Jeff Borzello contributed to this report.