The Blues kick off action back at home in a big derby match that will determined they're chances of reaching the playoffs, while the Crusaders take on the Bulls in their first clash of their South Africa tour.
Friday also sees a crucial Australian derby, while Sunday rugby returns with the Brumbies playing host to the Sunwolves.
(Note: All times are Australian Eastern Daylight Time)
Jump ahead to a particular game.
Blues vs. Hurricanes | Rebels vs. Reds | Bulls vs. Crusaders | Highlanders vs. Jaguares | Chiefs vs. Sharks | Lions vs. Waratahs | Brumbies vs. Sunwolves
Friday, May 10
Blues vs. Hurricanes, 5:35pm, Eden Park, Auckland
Blues: Melani Nanai, Tanielu Tele'a, TJ Faiane, Ma'a Nonu, Reiko Ioane, Harry Plummer, Sam Nock, Akira Ioane, Blake Gibson, Dalton Papalii, Josh Goodhue, Patrick Tuipulotu, Ofa Tuungafasi, James Parsons, Karl Tu'inukuafe. Replacements: Leni Apisai, Ezekiel Lindenmuth, Marcel Renata, Scott Scrafton, Jed Brown, Augustine Pulu, Otere Black, Matt Duffie.
Hurricanes: Jordie Barrett, Wes Goosen, Matt Proctor, Ngani Laumape, Ben Lam, Beauden Barrett, TJ Perenara, Reed Prinsep, Ardie Savea, Vaea Fifita, Isaia Walker-Leawere, James Blackwell, Jeff To'omaga-Allen, Asafo Aumua, Toby Smith. Replacements: Ricky Riccitelli, Fraser Armstrong, Ross Geldenhuys, Kane Le'aupepe, Du'Plessis Kirif, Finlay Chrisite, James Marshall, Chase Tiatia.
Melbourne Rebels vs. Queensland Reds, 7:45pm, AAMI Park, Melbourne
Rebels: Dane Haylett-Petty, Jack Maddocks, Billy Meakes, Reece Hodge, Marika Koroibete, Quade Cooper, Will Genia, Isi Naisarani, Angus Cottrell, Luke Jones, Matt Philip, Ross Haylett-Petty, Jermaine Ainsley, Anaru Rangi, Tetera Faulkner. Replacements: Hugh Roach, Matt Gibbon, Sam Talakai, Pone Fa'amausili, Rob Leota, Richard Hardwick, Michael Ruru, Campbell Magnay.
Reds: Hamish Stewart, Jock Campbell, Chris Feauai-Sautia, Samu Kerevi, Sefa Naivalu, Bryce Hegarty, Tate McDermott, Scott Higginbotham, Liam Wright, Angus Scott-Young, Angus Blyth, Izack Rodda, Taniela Tupou, Alex Mafi, JP Smith. Replacements: Brandon Paenga-Amosa, Harry Hoopert, Ruan Smith, Lukhan Salakaia-Loto, Caleb Timu, Moses Sorovi, Duncan Paia'aua, Isaac Lucas.
Saturday, May 11
Bulls vs. Crusaders, 3:10am, Loftus Versfeld, Pretoria
Bulls: Warrick Gelant, Cornal Hendricks, Johnny Kotze, Burger Odendaal, Rosko Specman, Handré Pollard (captain), André Warner, Duane Vermeulen, Jannes Kirsten, Marco van Staden, R.G. Snyman, Jason Jenkins, Trevor Nyakane, Schalk Brits, Lizo Gqoboka, Replacements: Jaco Visagie, Simphiwe Matanzima, Wiehahn Herbst, Thembelani Bholi , Paul Schoeman, Embrose Papier, Manie Libbok, Divan Rossouw .
Crusaders: David Havili, Sevu Reece, Jack Goodhue, Ryan Crotty, George Bridge, Richie Mo'unga, Bryn Hall, Kieran Read, Matt Todd, Jordan Taufua, Scott Barrett, Mitchell Dunshea, Michael Alaalatoa, Codie Taylor, Joe Moody. Replacements: Andrew Makalio, Harry Allan, Oliver Jager, Luke Romano, Whetukamokamo Douglas, Mitchell Drummond, Mitchell Hunt, Bradydon Ennor.
Highlanders vs. Jaguares, 3:15pm, Forsyth Barr Stadium, Dunedin
Highlanders: Matt Faddes, Jordan Hyland, Rob Thompson, Patelesio Tomkinson, Tevita Li, Josh Ioane, Aaron Smith, Elliot Dixon, James Lentjes, Luke Whitelock, Tom Franklin, Josh Dickson, Siate Tokolahi, Liam Coltman, Ayden Johnstone. Replacements: Ash Dixon, Daniel Leinert-Brown, Tyrel Lomax, Jack Whetton, Liam Squire, Kayne Hammington, Daniel Hollinshead, Thomas Umaga-Jensen.
Jaguares: Emiliano Boffelli, Sebastian Cancelliere, Matias Moroni, Jeronimo de la Fuente, Ramiro Moyano, Joaquin Diaz Bonilla, Felipe Ezcurra; Javier Ortega Desio, Tomas Lezana, Juan Manuel Leguizamon, Lucas Paulos, Marcos Kremer, Enrique Pieretto, Julian Montoya, Mayco Vivas. Replacements: Agustin Creevy, Juan Pablo Zeiss, Santiago Medrano, Tomas Lavanini, Pablo Matera, Tomas Cubelli, Domingo Motti, Matias Orlando.
Chiefs vs. Sharks, 5:35pm. FMG Stadium Waikato, Hamilton
Chiefs: Solomon Alaimalo, Sean Wainui, Tumua Manu, Anton Leinert-Brown, Etene Nanai-Seturo, Marty McKenzie, Brad Webber, Luke Jacobsen, Mitchell Karpik, Jesse Parete, Mitchell Brown, Tyler Ardron, Nepo Laulala, Nathan Harris, Atu Moli. Replacements: Liam Polwart, Ryan Coxon, Angus Ta'avao, Taleni Seu, Pita Gus Sowakula, Te Toiroa Tahuriorangi, Shaun Stevenson, Alex Nankivell.
Sharks: Aphelele Fassi, Sbu Nkosi, Lukhanyo Am, Marius Louw, Makazole Mapimpi, 10 Curwin Bosch, Louis Schreuder (c), Philip van der Walt, Jean-Luc du Preez, Jacques Vermeulen, Ruan Botha, Hyron Andrews, Coenie Oosthuizen, Kerron van Vuuren, Thomas du Toit. Replacements: Fezokuhle Mbatha, Mzamo Majola, John-Hubert Meyer, Tyler Paul, Luke Stringer, Cameron Wright, Robert du Preez, Kobus van Wyk.
Lions vs. Waratahs, 11:05pm, Ellis Park Johannesburg
Lions: Andries Coetzee, Courtnall Skosan, Lionel Mapoe, Harold Vorster, Aphiwe Dyantyi, Elton Jantjies, Ross Cronje, Warren Whiteley, Vincent Tshituka, Kwagga Smith, Marvin Orie, Stephan Lewies, Carlu Sadie, Malcolm Marx, Sti Sithole. Replacements: Jan-Henning Campher, Dylan Smith, Johannes Jonker, Wilhelm van der Sluys, Marnus Schoeman, Nic Groom, Shaun Reynolds, Tyrone Green.
Waratahs: Kurtley Beale, Alex Newsome, Lalakai Foketi, Karmichael Hunt, Cam Cark, Bernard Foley, Nick Phipps, Michael Wells, Michael Hooper, Ned Hanigan, Rob Simmons, Tom Staniforth, Sekope Kepu, Dmaien Fitzpatrick, Harry Johnson-Holmes. Replacements: Tolu Latu, Tom Robertson, Chris Talakai, Hugh Sinclair, Will Miller, Jake Gordon, Adam Ashley-Cooper, Curtis Rona.
Sunday, May 12
Brumbies vs. Sunwolves, 4:05pm, GIO Stadium, Canberra
Brumbies: Tom Banks, Henry Speight, Tevita Kuridrani, Irae Simone, Toni Pulu, Christian Leali'ifano; Pete Samu Jahrome Brown, Tom Cusack, Sam Carter, Darcy Swain, Allan Alaalatoa, Folau Fainga'a, Scott Sio. Replacements: Connal McInerney, James Slipper, Leslie Leuluaialii-Makin, Blake Enever, Murray Douglas, Ryan Lonergan, Tom Wright, Andy Muirhead.
Sunwolves: Ryohel Yamanaka, Gerhard van der Heever, Josh Timu, Phil Burleigh, Jason Emery, Yu Tamura, Kaito Shigeno, Rahboni Warren Vasayaco, Dan Pryor, Hendrick Tui, Grant Hattingh, Mark Abbott, Hiroshi Yamashita, Shota Horie, Masatake Mikami. Replacements: Jaba Bregvadze, Conan O'Donnell, Takuma Sahara, Tom Rowe, Kara Pryor, Ben Gunter, Jamie Booth, Hayden Parker.
BYE: Stormers