4:25 p.m. ET | FOX
Matchup rating: 39.1 | Spread: ARI -6 (54.5)
What to watch for: The Cardinals' offense keeps getting better every week, while the Lions have given up 27 and 42 points in the first two weeks, respectively. That doesn't bold well for Detroit taming Arizona, which should put on another offensive show and, perhaps, announce its arrival as one of the NFL's teams to watch this season. -- Josh Weinfuss
Bold prediction: Arizona quarterback Kyler Murray will have a 100-yard rushing and 250-yard passing day against the Lions. Detroit's defense has struggled against the run and the pass this season, a large part of their 0-2 start. Considering Detroit's inability to create a pass rush with its defensive line (one sack, one quarterback hit), Murray might have the option to either take off or sit back and watch. Watch for him to take advantage of it over and over again Sunday. -- Michael Rothstein
Stat to know: The Lions have lost 11 straight games, the longest active losing streak in the NFL and the team's longest since it dropped 19 in a row over the 2007-09 seasons. They have also lost four straight games dating back to last season in which they led by 10-plus points at some point, and according to the Elias Sports Bureau, the Lions are the first team in NFL history to blow a double-digit lead in four straight games.
What to know for fantasy: The list of active wide receivers with more touchdown receptions than Marvin Jones Jr. since 2017 is short: DeAndre Hopkins, Davante Adams and Tyreek Hill. See Week 3 rankings.
Betting nugget: The Lions have failed to cover in their last six road games. Read more.
Rothstein's pick: Cardinals 31, Lions 23
Weinfuss' pick: Cardinals 38, Lions 21
FPI prediction: ARI, 67.7% (by an average of 6.5 points)
Matchup must-reads: Can Sheila Ford Hamp's lifetime of experience turn around the Lions? ... Vacuum the floor? Workout at 5 a.m.? Cardinals' bolder Murray stays humble ... Lions keep losing double-digit leads ... Cardinals laud Murray's mobility through 2-0 start