8:20 p.m. ET | NBC
Matchup rating: 78 | Spread: SEA -3.5 (56)
What to watch for: Cardinals linebacker Dennis Gardeck didn't have a sack last weekend after posting two in Week 5 in his defensive debut. Watch for him to be a consistent presence in the Cardinals' pass rush and get a sack of Seattle's Russell Wilson. -- Josh Weinfuss
Bold prediction: Something ridiculous will happen. It usually does when the Seahawks play at State Farm Stadium. There was the inexplicable 6-6 tie in 2016, the Thursday night game in 2017 in which the Legion of Boom came undone with injuries to Richard Sherman and Kam Chancellor, and then the 2018 game in which Earl Thomas flipped the bird as he was carted off. Oh yeah, it's also where Malcolm Butler picked off Wilson to rip a second straight Super Bowl out of the Seahawks' hands. So what's next? How about Wilson leading another game-winning drive and hitting No. 3 tight end Jacob Hollister for the decisive touchdown? -- Brady Henderson
Stat to know: Wilson's 19 passing TDs are second most for a player through a team's first five games in NFL history. He needs three to tie the record for the most through a team's first six games (Peyton Manning, 22 in 2013). On the other side, Arizona QB Kyler Murray has five games this season with a passing TD and a rushing TD, the most by any player through the first six games of a season in NFL history. He would be the first player ever with six such games through a team's first seven games of a season.
What to know for fantasy: Don't forget how much potential these Seattle wide receivers have. In each of the first three weeks this season, both DK Metcalf and Tyler Lockett were top-20 performers at the position. See Week 7 rankings.
Betting nugget: The Cardinals are the only team to have every game go under this season. Read more.
Henderson's pick: Seahawks 31, Cardinals 27
Weinfuss' pick: Seahawks 24, Cardinals 21
FPI prediction: SEA, 58.0% (by an average of 2.8 points)
Matchup must-reads: Seahawks OC Schottenheimer getting bird's-eye view of Wilson's brilliance ... Drake motivated by mom ... Defense leaking, Wilson cooking: Five numbers on Seahawks' 5-0 start ... Why Cardinals' Hopkins honors Vesey on his helmet