As goes Kyler Murray, so goes the Arizona Cardinals’ offense.

So when Murray struggled to run the ball Thursday night against the Seahawks at Lumen Field in Seattle, the Cardinals’ offense struggled as well. Murray ran for 15 yards on five carries -- well below his average of 67.1 yards per game -- in the Cardinals' 28-21 loss to the Seahawks.

Seattle was able to contain Murray from the onset. His longest run was 8 yards -- and that was all he gained in the second half.

Without Murray able to make plays with his feet, the rest of the running game went stagnant as well. Starting running back Kenyan Drake ran for 29 yards and a touchdown on 11 carries, and Chase Edmonds finished with 13 yards on two carries, but he caught a touchdown pass.

Murray had three zone-read runs for 1 yard Thursday night. He had 18 zone-read runs for 140 yards and six touchdowns in the Cardinals’ five games leading into Thursday night. They were 4-1 in that span.

When Murray is held to fewer than 30 rushing yards, the Cardinals are 1-8-1.

The lack of a running game also impacted Murray's passing game Thursday night. None of his receivers had more than 62 yards. DeAndre Hopkins had five catches for 51 yards, and Edmonds had four catches for 36 yards and a touchdown. Larry Fitzgerald led the Cardinals with eight catches for 62 yards.

Troubling trend: The Cardinals couldn’t get out of their own way in Seattle. They were flagged for 10 penalties for 115 yards, their most since 2015. They lead the NFL in penalties.

QB breakdown: Murray finished with 269 yards and two touchdowns on 29-for-42 passing despite not being able to run the ball. He was seen grimacing when throwing the ball on the sideline in the first half, so his throwing shoulder might have been an issue.

Pivotal play: The Cardinals faced a second-and-22 on their own 2 with 9 minutes, 18 seconds left in the game, trailing 23-21, when guard J.R. Sweezy was flagged for a holding penalty in the end zone, which resulted in a safety. That gave Seattle a 25-21 lead and possession, which they turned into a field goal to take a 28-21 lead.

Eye-popping Next Gen Stat: Edmonds had 12 yards of separation on his receiving touchdown in the fourth quarter. That was the second-most separation for a Cardinals player on a Murray touchdown pass since the quarterback entered the league in 2019. That was also the second-most separation on a catch in the end zone this season. Calvin Ridley had 15.8 yards of separation on a Week 1 touchdown.