1 p.m. ET | FOX
Matchup rating: 70.5 | Spread: TB -6 (50.5)
What to watch for: Keep an eye on the protection for Carolina quarterback Teddy Bridgewater. He was sacked five times and pressured 15 times in a Week 2 loss to the Bucs. He threw two interceptions, and the Panthers' offense never got into a rhythm. But when Bridgewater has been kept relatively clean, he has played well. -- David Newton
Bold prediction: After being kept out of the end zone for the first time this season in a 38-3 loss to the Saints last Sunday night, Tom Brady and the Bucs rebound with a five-touchdown performance. Coming off their two previous losses earlier this season (Saints in Week 1 and Bears in Week 5), the Bucs combined for 69 points (nine touchdowns) in Week 2 and Week 6. One of those games came against the Panthers, who are still struggling to get off the field on third down and can't get to the quarterback. -- Jenna Laine
Stat to know: The Buccaneers are allowing just 77.9 rushing yards per game and 3.3 per rush this season, both the best in the NFL. And the Panthers will likely be without starting running back Christian McCaffrey.
What to know for fantasy: Brady struggled all night long in Week 9 on his way to 2.4 fantasy points. But in the game immediately following his past four single-digit performances, the future Hall-of-Famer has averaged 21.3 fantasy points. See Week 10 rankings.
Betting nugget: Brady is 19-6 against the spread (ATS) in his career after a loss, with 17 covers in his last 20 such games. And he's 7-1 ATS coming off a 20-plus-point loss. However, Bridgewater is 21-4 ATS in his career as an underdog, including five straight covers as an underdog this season. Read more.
Laine's pick: Buccaneers 30, Panthers 21
Newton's pick: Buccaneers 24, Panthers 20
FPI prediction: TB, 64.5% (by an average of 5.0 points)
Matchup must-reads: How can Bucs' Brady and Evans get back on track? ... Panthers rookie Chinn harder to replace than McCaffrey ... Breaking down what went wrong for Bucs in worst loss of Brady's career ... Bridgewater will give best Brady look to end Panthers' skid