4:05 p.m. ET | CBS
Matchup rating: 18.8 | Spread: LAC -9.5 (46)
What to watch for: The Jets, who are looking to 35-year-old Joe Flacco in place of an injured Sam Darnold, are 0-6 in games started by QBs other than Darnold since the start of last season (7-12 with Darnold). The Chargers, meanwhile, will be looking to avoid their first 2-8 start since 2015. Quarterback play shouldn't be a concern for them, though, as Justin Herbert has thrown multiple TDs in six consecutive games -- the longest streak by a rookie in NFL history, per Elias Sports Bureau research -- and is the only rookie in Chargers history with at least four 300-yard passing games in a season. The Jets will need to find a way to contain Herbert's big arm if they want to enter the win column this weekend. -- Shelley Smith
Bold prediction: Herbert will set a career high for passing yardage, meaning he will go north of 347 on the day. The Jets' pass defense is awful, and there's a good chance it will be breaking in a new set of cornerbacks. CB1 Pierre Desir was cut this week, and CB2 Bless Austin could sit out with a neck injury. The Jets could wind up starting three rookies in the secondary. Have at it, Justin. -- Rich Cimini
Stat to know: All seven of the Chargers' losses this season have been one-score games. That is tied for the most in a team's first nine games in NFL history, per research by the Elias Sports Bureau (2015 Ravens, 1983 Buccaneers and 1944 Brooklyn Tigers).
What to know for fantasy: Chargers tight end Hunter Henry has seen at least six targets in four of his past five games, and while the production has been spotty, don't forget that he ranks as a per-game top-10 player at the position among healthy options. See Week 11 rankings.
Betting nugget: Six straight Los Angeles games have gone over the total, and the over is 6-2 in Herbert starts. Read more.
Cimini's pick: Chargers 31, Jets 14
Smith's pick: Chargers 17, Jets 7
FPI prediction: LAC, 69.9% (by an average of 7.0 points)
Matchup must-reads: Gase: Jets trying to play young guys, not tank ... Killer handshake: How Chargers rookie Herbert learned to cope with losing ... Sudden fall: Jets' Darnold goes from savior to potential trade chip