1 p.m. ET | FOX
Matchup rating: 41.8 | Spread: PHI -6.5 (43)
What to watch for: There are two key matchups. First, keep an eye on Washington's defensive front, the strength of the team, vs. the Eagles' offensive line, which has been weakened. But the second is Washington wide receiver Terry McLaurin against Philly cornerback Darius Slay. McLaurin caught five passes for 72 yards in a matchup versus Slay when he played for Detroit last season, and in two games against the Eagles, he caught a combined 10 passes for 255 yards and two touchdowns. -- John Keim
Bold prediction: Chase Young will begin his NFL career with a pair of sacks. The Eagles' offensive line had a rough summer, losing a pair of starters to injury in Brandon Brooks and Andre Dillard, while a third, Lane Johnson, was hobbled for much of camp with an ailing ankle. Jason Peters, 38, moved back out to left tackle this week after training this offseason at guard and will have to quickly adjust to fend off Young and the rest of Washington's formidable pass-rushers. -- Tim McManus
Stat to know: In seven career starts against Washington, Eagles quarterback Carson Wentz has a 5-2 record with 15 passing touchdowns.
What to know for fantasy: The Eagles ended the 2019 regular season on a four-game win streak and led the league in running back fantasy points over that stretch (163). That run included a game in Washington (Week 15) in which Miles Sanders scored a season-high 35.2 points. See Week 1 rankings.
Betting nugget: The Eagles have won the past six games in this series, covering in five of them. Read more.
McManus' pick: Washington 24, Eagles 23
Keim's pick: Eagles 24, Washington 20
FPI prediction: PHI, 70.8% (by an average of 7.9 points)
Matchup must-reads: After kicking down doors, Wentz has found his voice ... How Washington's Gibson made Peterson expendable ... Eagles 2020 season preview: Wentz needs O-line to hold up ... Washington 2020 season preview: Can Haskins lead a turnaround? ... Eagles' Peters gets pay bump for move to LT