To help you set your lineups and avoid starting a player who won't take the field, we will post fantasy-relevant updates and analysis here as NFL teams release their inactives lists, typically about 90 minutes before kickoff. Any rankings cited in this column come from our ESPN Fantasy staff ranks.
Refresh often for the latest information.
4 p.m. ET games
Offense
Chase Edmonds, RB, ARI: Hamstring -- OUT
Impact: Kenyan Drake and David Johnson should rotate at RB.
A.J. Green, WR, CIN: Ankle -- OUT
Impact: Apparently, the 11th time is not the charm.
Matt LaCosse, TE, NE: Knee -- Active
Impact: Tom Brady has plenty of other options, although fellow TE Ryan Izzo sits.
Dwayne Harris, WR, OAK: Foot -- Inactive
Impact: Zay Jones could see some looks. Keelan Doss is also inactive.
Jordan Howard, RB, PHI: Shoulder -- Inactive
Impact: Miles Sanders and (potentially) Jay Ajayi could step up.
Alshon Jeffery, WR, PHI: Ankle -- OUT
Impact: Against the tough Patriots defense, don't expect any WR success from the Eagles.
Matt Breida, RB, SF: Ankle -- Inactive
Impact: Tevin Coleman should get the majority of carries ...
Raheem Mostert, RB, SF: Knee -- Active
Impact: ... but Mostert might get his fair share of touches, too.
Emmanuel Sanders, WR, SF: Ribs -- Active
Impact: Didn't practice all week but is suiting up. Still, Deebo Samuel might shine.
Dante Pettis, WR, SF: Back -- Active
Impact: Kendrick Bourne might be a flex option anyway.
George Kittle, TE, SF: Knee -- Inactive
Impact: Expect Ross Dwelley to be the man in his place.
Robbie Gould, K, SF: Quadriceps -- Inactive
Impact: Chase McLaughlin made 3 of 4 FG attempts in his 49ers debut.
Defense
Jonathan Bullard, DE, ARI: Foot -- OUT
Terrell Suggs, LB, ARI: Hamstring -- Active
Geno Atkins, DT, CIN: Ankle -- Active
John Simon, DE, NE: Elbow -- Active
Danny Shelton, DT, NE: Ankle -- Active
Patrick Chung, S, NE: Heel -- Inactive
Lamarcus Joyner, S, OAK: Hamstring -- OUT
Nigel Bradham, LB, PHI: Ankle -- OUT
D.J. Jones, DT, SF: Groin -- OUT
Azeez Al-Shaair, LB, SF: Concussion -- Inactive
Ahkello Witherspoon, CB, SF: Foot -- Active
Official Sunday inactives should begin coming in at approximately 11:30 a.m. ET for the early games and 2:30 p.m. ET for the late games.
1 p.m. ET games
Offense
Devonta Freeman, RB, ATL: Foot -- OUT
Impact: Brian Hill is the biggest beneficiary of Freeman's injury.
Austin Hooper, TE, ATL: Knee -- OUT
Impact: Expected to miss about a month. Luke Stocker to start, but unlikely to make waves.
Marquise Brown, WR, BAL: Ankle -- Active
Impact: Played through injuries in the past. Willie Snead IV would step in if he stumbles.
DaeSean Hamilton, WR, DEN: Knee -- Active
Impact: The just-activated Tim Patrick might still make an impact.
Jeff Heuerman, TE, DEN: Knee -- Inactive
Impact: Noah Fant becomes interesting as a TE flier.
Matthew Stafford, QB, DET: Back -- OUT
Impact: Jeff Driskel again will start, impacting all Lions receivers.
Ty Johnson, RB, DET: Concussion -- Active
Impact: Removed from protocol on Saturday, so will be able to play.
Will Fuller V, WR, HOU: Hamstring -- OUT
Impact: DeAndre Hopkins and Kenny Stills get another week of increased targets.
T.Y. Hilton, WR, IND: Calf -- OUT
Impact: Zach Pascal gets QB Jacoby Brissett back.
Parris Campbell, WR, IND: Hand -- OUT
Impact: Devin Funchess might return from IR.
Seth DeValve, TE, JAX: Oblique -- Inactive
Impact: Josh Oliver is the TE to have on the Jaguars.
Adam Thielen, WR, MIN: Hamstring -- OUT
Impact: Bisi Johnson gets a shot at No. 2 WR duties in Minnesota.
Deonte Harris, WR, NO: Hamstring -- OUT
Impact: Tre'Quan Smith is the Saints WR to take a flier on.
Le'Veon Bell, RB, NYJ: Ribs -- Active
Impact: Limited practice on Friday, but will suit up. Be cautious.
Demaryius Thomas, WR, NYJ: Knee -- Active
Impact: With Robby Anderson also dinged up, avoid the Jets' offense.
Chris Thompson, RB, WAS: Toe -- OUT
Impact: Derrius Guice and Adrian Peterson likely to be involved in some sort of timeshare.
Paul Richardson Jr., WR, WAS: Hamstring -- OUT
Impact: No real reason to trust any replacement here with rookie Dwayne Haskins now at QB.
Vernon Davis, TE, WAS: Concussion -- OUT
Impact: Jeremy Sprinkle has yet to prove he's useful for fantasy purposes.
Defense
Kemal Ishmael, LB, ATL: Concussion -- OUT
Michael Pierce, DT, BAL: Ankle -- Inactive
Jerry Hughes, DE, BUF: Groin -- Active
Donte Jackson, CB, CAR: Hip -- Active
Jeff Heath, S, DAL: Shoulder -- Inactive
Damon Harrison Sr., DT, DET: Groin -- Active
Romeo Okwara, DE, DET: Groin -- Inactive
Tracy Walker, S, DET: Knee -- Active
Tashaun Gipson Sr., S, HOU: Back -- Active
Bradley Roby, CB, HOU: Hamstring -- Inactive
Pierre Desir, CB, IND: Hamstring -- Inactive
Taco Charlton, DE, MIA: Elbow -- Inactive
Raekwon McMillan, LB, MIA: Knee -- Inactive
Linval Joseph, DT, MIN: Knee -- OUT
Anthony Harris, S, MIN: Groin -- OUT
Marshon Lattimore, CB, NO: Hamstring -- OUT
Steve McLendon, DT, NYJ: Neck -- Active
Henry Anderson, DE, NYJ: Shoulder -- Active
C.J. Mosley, LB, NYJ: Groin -- OUT
Neville Hewitt, LB, NYJ: Neck -- Active
Brandon Copeland, LB, NYJ: Hip -- Active
Darryl Roberts, CB, NYJ: Calf -- Inactive
Carl Nassib, DE, TB: Groin -- OUT
Carlton Davis, CB, TB: Hip -- Active
Montae Nicholson, S, WAS: Ankle -- Active