Barcelona have said Luis Suarez will be sidelined for around two weeks after spraining an ankle in Sunday's win at Real Betis.
Suarez scored as Barca triumphed 4-1 in Seville to move 10 points clear at the top but was unable to finish the match after taking a knock to his ankle in the closing stages.
After undergoing tests at the training ground on Monday, he has pulled out of the Uruguay squad for this week's China Cup.
Uruguay face Uzbekistan in the semifinal in Nanning on Friday and then play either the final or a third place playoff against China or Thailand next Monday.
But Suarez could be back for Barca's next fixture, the Catalan derby against Espanyol at Camp Nou on March 30.
The striker was one of a handful of players at the training ground on Monday as the majority of the squad departed for international duty.
Coach Ernesto Valverde has given the non-internationals the week off but is holding voluntary training sessions on Monday and Tuesday.