The 16-year-old has already set several records at club level and could become the youngest U21 international in Germany's history if he makes his debut.
"With Youssoufa Moukoko we have an extraordinary talent here in Germany which we want to promote carefully and performance orientated," Germany U21 coach Stefan Kuntz said.
"In close consultation with Borussia Dortmund, we have therefore decided to nominate him because we think that his participation will help both the team and him in his development."
He has featured in 14 competitive matches for the senior squad so far, but only started in two games.
Despite only playing a total of 366 Bundesliga minutes, Moukoko has already scored three goals in the German top flight with his latest coming in Saturday's 2-0 win over Hertha Berlin.
Germany take on hosts Hungary, followed by the Netherlands and Romania in the group stage of the U21 tournament in late March.