Athletic Club head coach Marcelino will take on his former club Valencia in the semifinals of the Copa del Rey. (Stream live on ESPN+ on Feb. 9)
Rayo Vallecano, the only team left in the competition that has yet to win the title, were drawn against Real Betis in the other tie.
- Stream the Copa del Rey on ESPN+ (U.S. only)
- Don't have ESPN? Get instant access
Athletic, who have lost in the final in the two previous editions, eliminated holders Barcelona in the round of 16 before edging Real Madrid 1-0 on Thursday.
Marcelino steered Valencia to Copa del Rey glory in 2019 but was dismissed the following season.
Valencia eliminated relegation-threatened Cadiz.
In-form Real Betis, who are third in LaLiga, eliminated city rivals Sevilla before brushing aside Real Sociedad in San Sebastian 4-0 on Thursday.
Rayo reached their first Copa semifinal in 40 years by scraping a 1-0 win against Mallorca.
The Madrid outfit has been among the surprises in La Liga and are eighth in the standings.
The first legs will take place on Feb. 9-10 and return matches on March 2-3.
The final will be played on April 23 in Seville.