Tyrique Jones scored 12 with 18 rebounds and three blocks for the Musketeers (15-8, 4-6 Big East Conference), who outrebounded the Blue Demons 50-37. Quentin Goodin added 12 points and Naji Marshall had nine with seven assists.
Xavier hit eight 3-pointers in the opening half, with Goodin and Scruggs making back-to-back triples, and the Musketeers led 35-16 at halftime after shooting 44% percent from beyond the arc (8 of 18).
DePaul's 16 first-half points was a season low for the team.
Paul Reed scored 18 points with nine rebounds and seven steals and for DePaul (13-10, 1-9), which has lost five straight. Jalen Coleman-Lands added 17 points and Charlie Moore had 10 and eight assists.
Xavier takes on Providence at home on Saturday. DePaul faces Georgetown on the road on Saturday.
For more AP college basketball coverage: https://apnews.com/Collegebasketball and http://twitter.com/AP-Top25
Elements of this story were generated by Automated Insights, http://www.automatedinsights.com/ap, using data from STATS LLC, https://www.stats.com
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