Swanson was thrown out at first base by shortstop Troy Tulowitzki after hitting a drive off a leg of pitcher Stephen Tarpley in the first inning of a 5-1 loss to the New York Yankees on Tuesday. He singled to right and scored during the fourth.
The 25-year-old hit .238 with 14 home runs and 59 RBIs in 136 games last season. He was left off the National League Division Series roster against the Los Angeles Dodgers after tearing a ligament in his left wrist late in the season.
Swanson saw his first appearance pushed back from Friday because of discomfort stemming from scar tissue in his left hand while taking batting practice.