Victor Wembanyama and Stephon Castle sat out the San Antonio Spurs' 112-101 victory over the Portland Trail Blazers on Wednesday night.
Wembanyama was out after suffering a bruised rib Monday and Castle was out because of right knee soreness, the team announced.
Wembanyama needs to play at least 20 minutes in one more game to reach the league-required minimum of 65 games for award eligibility.
The Spurs have two games left in the regular season after Wednesday night: Friday against the Dallas Mavericks and Sunday against the Denver Nuggets.
The Spurs said they were hopeful Wembanyama and Castle would play Friday.
They both participated in shootaround Wednesday.
"I can't tell you too much of how [Wembanyama] looked, but he heals fast," Spurs veteran Harrison Barnes said.
Wembanyama suffered the injury in the first half of a 115-102 victory over the Philadelphia 76ers. Castle had 17 points, 13 assists and 10 rebounds in that game.
Wembanyama had 17 points, five rebounds and three blocks in just under 16 minutes. That time constituted an official game per the NBA guidelines, which allow two exceptions of 15 to 19:59 minutes to count toward the league-required minimum.
San Antonio (60-19) has clinched the Southwest Division and is assured of finishing no worse than second in the Western Conference. It trails the conference-leading Oklahoma City Thunder (63-16) by three games.
The Associated Press contributed to this report.