Week 2 of NFL action brought injury after injury, some of the season-ending variety. The Giants lost Saquon Barkley to a torn ACL. The Panthers will be without Christian McCaffrey for at least three weeks because of a high ankle sprain. Those running backs were the top two picks in most fantasy football leagues.
The 49ers sustained more injuries than they could imagine, including a torn ACL for Nick Bosa. The news wasn't much better in Denver or Indianapolis.
NFL Nation is here to sort out all that has happened and answer the biggest fantasy questions -- provided by ESPN fantasy football analyst Mike Clay -- across the league for Week 3.
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Buffalo Bills
Can we trust Stefon Diggs again this week despite potential shadow coverage from Jalen Ramsey?
Trust him to put up the same numbers he did over the first two weeks of the season? Probably not. But considering his role in the Bills' suddenly pass-heavy offense, Diggs is still likely to see enough volume to produce moderate fantasy numbers. Fire him up in your starting lineup but temper expectations a bit. -- Marcel Louis-Jacques
Miami Dolphins
Is Ryan Fitzpatrick doing enough to remain the starter or will we see Tua Tagovailoa in the near future?
Fitzpatrick probably tamped down public calls for him to be replaced by Tagovailoa after completing 90% of his passes and accounting for three touchdowns Thursday night. But that performance came against the Jaguars' defense, one of the league's worst. So while there is no immediate need or desire to bench him now, there is also no reason to believe he has indefinitely secured his spot. -- Kevin Seifert
New England Patriots
Will N'Keal Harry continue to see roughly 30% of Cam Newton's targets?
Yes. The two have a growing chemistry and Harry is playing the majority of offensive snaps, so he should have a chance to hit that number (or at least close to it). Newton went to Harry multiple times with the game on the line this past Sunday, and Harry said, "It means that he trusts me in the critical situation. That's all I can ask for as a receiver. It's my job to help him gain confidence, not only throughout the game, but throughout the season. I take a lot of pride in that." -- Mike Reiss
New York Jets
What has gone wrong with Chris Herndon, and will he get back on track this week?