The NRL will place State of Origin players back in a biosecurity bubble to ensure Game II can go ahead in Brisbane on Sunday, after retrospective stay-at-home orders were issued for several parts of Sydney.
Queensland Health on Friday announced any arrivals who had been in four coronavirus-affected Sydney local government areas (LGAs) since June 11 must quarantine from 1am on Saturday.
That had an immediate impact on Origin, with the retrospective orders pre-dating when NSW left for their training camp just south of the Queensland border in Kingscliff on Monday.
James Tedesco, Latrell Mitchell, Damien Cook, Cameron Murray, Angus Crichton all play for clubs in the Sydney LGA.
Queensland forward Jai Arrow is another to fit that category, and would have been at South Sydney training at Redfern since June 11.
As a result the NRL has implemented the same level-three restrictions the game was played under at the end of last year, with clean and dirty zones in the stadium
"We are dealing with the Queensland government and adapting to their change in protocol," ARL Commission chairman Peter V'landys told AAP.
"We are confident of the outcomes. The Queensland government has been extremely professional with us and cooperative.
"We will continue to work with them. We don't believe there is any problem with the game."
V'landys and NRL staff were set to fly home before the orders come into place, with their office at Moore Park situated inside the City of Sydney LGA.
The Blues are already without doctors Nathan Gibbs and Paul Arnett and physio Travis Touma after they were unable to enter Queensland from the hotspot areas.
It is unclear what the ban on people who live or have visited Sydney, Randwick, Waverley or Woollahra LGAs since June 11 will have on key production and match-day staff.
The changes come after players in Sydney were placed into level-three restrictions earlier in the week in a bid to avoid any major disruptions to NRL games in the city during the outbreak.
Origin III is still scheduled for ANZ Stadium on July 14, however, attention will likely turn to that next.
There are still four games planned for Sydney next week, after the Sydney Roosters moved their clash with Melbourne to Newcastle.
Remaining games are likely to be played with 50 per cent crowds at best, with that order extended until next Friday at least.
Meanwhile, the only international of the weekend - a clash between Lebanon and Malta at Belmore on Saturday - has also been postponed.