Australia's playmaking depth will be tested against Japan on Saturday, with Reece Hodge and Nick Phipps named in the halves after injury and illness forced multiple changes for the historic Test match in Yokohama.
Regular five-eighth Bernard Foley has been ruled out of the match after being struck down by a gastro bug while halfback Will Genia failed to overcome a calf injury suffered in the Wallabies' win over New Zealand last month.
Karmichael Hunt has also been sidelined after injuring his neck at training on Tuesday, with Kurtley Beale shifting to fullback, Samu Kerevi partnering Tevita Kuridrani in the centres and Henry Speight taking Hodge's wing berth.
Hodge played four Tests at inside centre after making his international debut last year before moving this season to the wing, where he has been a revelation. But with coach Michael Cheika overlooking Quade Cooper for the four-Test tour, the versatile 23-year-old was the first-choice back-up.
Hodge spent the bulk of his junior career as five-eighth and some time there with the Melbourne Rebels but Saturday's match marks his Test debut in the No.10 jersey.
Former Western Force lock Matt Philip, 23, has been named to make his Test debut from the bench as Australia plays its first Test against the Brave Blossoms on Japanese soil. Halfback Joe Powell and utility back Curtis Rona round out the bench, as both aim to add to their two Test caps.
The trio of Foley, Genia and Hunt are all expected to be available for the Wallabies' first Test in the UK, against Wales next week.
Australia: Kurtley Beale, Henry Speight, Tevita Kuridrani, Samu Kerevi, Marika Koroibete, Reece Hodge, Nick Phipps, Sean McMahon, Michael Hooper, Ned Hanigan, Adam Coleman, Rob Simmons, Sekope Kepu, Tatafu Polota-Nau, Scott Sio. Reserves: Stephen Moore, Tom Robertson, Allan Alaalatoa, Matt Philip, Ben McCalman, Lopeti Timani, Joe Powell, Curtis Rona.