Expert picks: Predicting the Sweet 16

Sweet 16 stars to watch (2:28)

It's down to 16 teams in the NCAA tournament with a ton of talent on the court. Rebecca Lobo and Andy Landers break down notable players to watch such as Oregon's Sabrina Ionescu, Texas A&M's Chennedy Carter, South Carolina's A'Ja Wilson and more. (2:28)

For just the third time, two teams seeded No. 11 or lower reached the regional semifinals. But can 11-seeds Buffalo and Central Michigan -- a pair of Mid-American Conference teams which are in the regional semifinals for the first time -- bring the #MACtion to the Elite Eight?

Double-digit seeds are just 3-20 all time in the Sweet 16, with 11th-seeded Gonzaga (2011), 10th-seeded Oregon (2017) and 10th-seeded Lamar (1991) as the only teams to reach the regional finals.

According to ESPN's Basketball Power Index, there is an 8.2 percent chance that all four No. 1 seeds reach the Final Four. Top-seeded UConn has a 68 percent chance to meet defending NCAA champion South Carolina in the next round. And second-seeded Baylor has a 48 percent chance to reach the national semifinals.

The Sweet 16 -- which includes four teams each from the ACC and Pac-12 -- tips off Friday. Until then, Pat Borzi, Charlie Creme, Graham Hays, Kevin Pelton and Mechelle Voepel cast their predictions.