Lee was a second-team All-America selection by The Associated Press last season.
"I am devastated for Yokie," Mittie said. "She has battled this knee injury for two years. We were hopeful with a summer procedure and extended rest, she would be able to play this upcoming season. Unfortunately, after meeting with the medical staff the last couple of days she will require season-ending surgery."
Lee averaged a school-record 22.0 points last season, while adding 339 rebounds, 95 blocks, 39 steals and 20 double-doubles. She became the first woman in school history to record more than 725 points, more than 325 rebounds and more than 90 blocks in a season.