Osasuna have sacked coach Petar Vasiljevic following his failure to keep the club in La Liga.
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Barcelona followed up Sunday's thrilling Clasico victory with a 7-1 thrashing of lowly Osasuna to further keep their La Liga title hopes alive.
"I've already said that we need a plan for Messi and the players told me [that we need to] carry handcuffs and a pistol," Osasuna's coach said.
Atletico Madrid kept themselves ahead in the battle with Sevilla for third place after a 3-0 win over bottom club Osasuna.
Atletico Madrid defeated Malaga 2-0 to secure their fourth consecutive win and regain third place in La Liga on Saturday.
Kenan Kodro struck a late equaliser as rock-bottom Osasuna ended their six-match losing streak with a 1-1 draw at home to Eibar.
Real Madrid scored three goals after the hour mark to secure a sensational 3-2 come-from-behind victory over Villarreal in La Liga action on Sunday.
The injury happened midway through the first half of the game at El Sadar, with Tano coming out the worst after a collision between he and Isco.
Cristiano Ronaldo and Isco scored to help Real Madrid to a slim 3-1 win at bottom side Osasuna.
Samir Nasri passed up the chance to fire Sevilla closer to La Liga leaders Real Madrid from the penalty spot.
Osasuna have signed Italy international goalkeeper Salvatore Sirigu for the remainder of the season, the Liga club have announced.
Osasuna wasted the chance to move off the foot of La Liga by drawing 1-1 at home with Malaga.
With a remarkable injury time goal, Real Madrid salvaged a 3-3 draw against Sevilla in the Copa del Rey to set a Spanish record of 40 games unbeaten.
Carlos Clerc struck a dramatic stoppage-time equaliser as bottom club Osasuna came from behind three times to grab a 3-3 draw against Valencia.
Osasuna president Luis Sabalza believes Petar Vasiljevic is the right man to lead the club as they attempt to fight off relegation from La Liga.
Osasuna have sacked head coach Joaquin Caparros just two months into his reign and appointed sporting director Petar Vasiljevic in his place.
Atletico Madrid eased to a first-leg win against Las Palmas in the Copa del Rey on Tuesday, while Celta Vigo piled on Valencia's season-long woe.
Barcelona ended a run of three straight draws as they beat La Liga's bottom side Osasuna 3-0 on Saturday thanks to Messi and Suarez.
Barca carved out a string of chances in a dominant display against their bottom of the table hosts.
Luis Enrique hopes the Champions League win over Borussia Monchengladbach will provide the spark Barcelona need to get league form back on track.
Neymar has warned Real Madrid not to get too comfortable at the top of the La Liga table.
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