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31 Mar
Brandon Aiyuk
WR
Status
Questionable
GM John Lynch relayed Monday that Aiyuk, who tore the ACL and MCL in his right knee in October, met with Dr. Neal ElAttrache last week and got "good reviews" in terms of the progress he's made in his recovery, Nick Wagoner of ESPN.com reports.
14 Mar
Tre Brown
CB
Status
Questionable
Brown (knee) signed with the 49ers on Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports.
10 Mar
Kevin Givens
DT
Status
Questionable
The 49ers re-signed Givens (pectoral) to a one-year contract Monday, Matt Barrows of The Athletic reports.
26 Feb
Trent Williams
OT
Status
Questionable
San Francisco general manager John Lynch said Wednesday that Williams (ankle) is "motivated" and will return for a 16th NFL season in 2025, Ian Rapoport of NFL Network reports.
13 Feb
Mitch Wishnowsky
P
Status
Questionable
George Odum
S
Status
Questionable
Christian McCaffrey
RB
Status
Questionable
Darrell Luter Jr.
CB
Status
Questionable
Drake Jackson
DE
Status
Questionable
Spencer Burford
OT
Status
Questionable
17 Jan
Malik Mustapha
S
Status
Questionable
Mustapha (knee) finished his rookie season with 72 tackles (32 solo) and one interception across 16 games with the 49ers.
Deommodore Lenoir
CB
Status
Questionable
Lenoir (shoulder) finished with 85 tackles (53 solo), two interceptions and one forced fumble across 15 starts in 2024.
9 Jan
Renardo Green
CB
Status
Questionable
Green (groin) finished the 2024 regular season with 61 tackles (41 solo), 13 pass defenses (including one interception) and one forced fumble across 17 games.
7 Jan
Isaac Guerendo
RB
Status
Questionable
Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The Athletic reports.
6 Jan
Robert Beal Jr.
DE
Status
Questionable
Colton McKivitz
OT
Status
Questionable
