| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Baker Mayfield |
1. Baker Mayfield, QB | TB | L 31-23 at DET | 26 | 41 | 349 | 3 | 2 | 4 | 0 | 94.4 |
| 2. Jared Goff, QB | DET | W 31-23 vs. TB | 30 | 43 | 287 | 2 | 0 | 2 | 0 | 103.5 | |
| 3. Brock Purdy, QB | SF | W 24-21 vs. GB | 23 | 39 | 252 | 1 | 0 | 1 | 0 | 86.7 | |
| 4. Patrick Mahomes, QB | KC | W 27-24 at BUF | 17 | 23 | 215 | 2 | 0 | 0 | 0 | 131.6 | |
| 5. Jordan Love, QB | GB | L 24-21 at SF | 21 | 34 | 194 | 2 | 2 | 0 | 0 | 72.4 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Aaron Jones |
1. Aaron Jones, RB | GB | L 24-21 at SF | 18 | 108 | 6.0 | 0 | 53 | 0 | |
| 2. Lamar Jackson, QB | BAL | W 34-10 vs. HOU | 11 | 100 | 9.1 | 2 | 23 | 0 | ||
| 3. Christian McCaffrey, RB | SF | W 24-21 vs. GB | 17 | 98 | 5.8 | 2 | 39 | 0 | ||
| 4. Isiah Pacheco, RB | KC | W 27-24 at BUF | 15 | 97 | 6.5 | 1 | 29 | 0 | ||
| 5. Jahmyr Gibbs, RB | DET | W 31-23 vs. TB | 9 | 74 | 8.2 | 1 | 31 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Mike Evans |
1. Mike Evans, WR | TB | L 31-23 at DET | 8 | 147 | 18.4 | 1 | 29 | 0 | |
| 2. Romeo Doubs, WR | GB | L 24-21 at SF | 4 | 83 | 20.8 | 0 | 38 | 0 | ||
| 3. George Kittle, TE | SF | W 24-21 vs. GB | 4 | 81 | 20.3 | 1 | 32 | 0 | ||
| 4. Amon-Ra St. Brown, WR | DET | W 31-23 vs. TB | 8 | 77 | 9.6 | 1 | 16 | 0 | ||
| 5. Travis Kelce, TE | KC | W 27-24 at BUF | 5 | 75 | 15.0 | 2 | 29 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Lavonte David |
1. Lavonte David, LB | TB | L 31-23 at DET | 9 | 4 | 13 | 1.0 | 0 | 0 | 0 |
| 2. Nick Bolton, LB | KC | W 27-24 at BUF | 5 | 8 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. K.J. Britt, LB | TB | L 31-23 at DET | 7 | 5 | 12 | 0.0 | 0 | 0 | 0 | |
| 4. Justin Reid, S | KC | W 27-24 at BUF | 8 | 3 | 11 | 0.0 | 0 | 0 | 0 | |
| 5. Chamarri Conner, S | KC | W 27-24 at BUF | 8 | 2 | 10 | 0.0 | 1 | 0 | 0 | |