- Brayan Angulo (4' OG)
- Jonathan Mensah (74')
- Etienne Jr.22
1:00 AM, 30 September 2021
Columbus, Ohio, USA
Match ends, Columbus Crew 2, Cruz Azul 0.
Second Half ends, Columbus Crew 2, Cruz Azul 0.
Attempt blocked. Santiago Giménez (Cruz Azul) left footed shot from outside the box is blocked. Assisted by Orbelín Pineda.
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