Virgil van Dijk will undergo knee surgery and is facing a battle to play again this season after scans confirmed that he suffered an ACL injury.
2020 ScheduleAll times ET
Italy and the Netherlands' 1-1 draw is further evidence that both face uphill challenges under mediocre managers Roberto Mancini and Frank de Boer.
Italy extended their unbeaten run to 19 games with a 1-1 draw at home to the Netherlands on Wednesday.
Bosnia and Herzegovina put the disappointment of European Championship playoff elimination behind them to hold the Netherlands to a goalless draw.
UEFA Nations League resumes amid COVID-19 fears: England need wins after off-field drama, Spain stress
The October international break is jam-packed with action and England, France, Spain, Germany and Italy all have issues to deal with.
Mexico handed new Netherlands coach Frank de Boer a defeat in his first game in charge as they enjoyed a deserved 1-0 win over their hosts.
Former Atlanta United boss Frank de Boer has been named as Netherlands manager following Ronald Koeman's departure to Barcelona.
Italy returned to winning ways as Nicolo Barella's header just before halftime secured a 1-0 victory away to a below-par Netherlands.
Netherlands forward Steven Bergwijn scored just past the hour mark to secure a hard-fought 1-0 win over Poland in their Nations League clash.
England, Portugal, France and Netherlands were among countries to release new kits, and the big stars were about to don the new designs.
The Netherlands team are disappointed with their coach Ronald Koeman's decision to leave for Barcelona but understand, says Virgil van Dijk.
Ronald Koeman has a clause in his contract with the Dutch FA which lets him leave the national side should Barcelona want him.
Ellen Fokkema, 19, is the first player to participate in the new pilot and will play with VV Foarut's first team.