Barnes is 5-2 with 23 saves and a 2.30 ERA, but hadn't pitched since a save against the Toronto Blue Jays on July 28. The right-hander was put into quarantine after showing symptoms at the team's hotel in Detroit.
Manager Alex Cora said Barnes is expected back on Wednesday.
Marwin González returned to the active roster after being out since July 13 with a hamstring strain. He is hitting .205 while starting at all four infield positions, as well as left and right field.
Houston will look to extend series lead over Boston in Game 2
Boston Red Sox (92-70, second in the AL East) vs. Houston Astros (95-67, first in the AL West)
Atlanta will play Los Angeles in the opening game of the NLCS
Atlanta Braves (88-73, first in the NL East) vs. Los Angeles Dodgers (106-56, second in the NL West)
2021 MLB playoffs - Enrique Hernández's impressive performance draws praise from Houston Astros manager Dusty Baker
Enrique Hernández continued his impressive postseason run and Astros manager Dusty Baker had nothing but praise for the Red Sox center fielder during an in-game interview.
Houston Astros stars Jose Altuve, Carlos Correa down Red Sox with homers in ALCS Game 1 win
Friday's win marked the fourth postseason game where Jose Altuve and Carlos Correa both hit homers, the most by a pair of infield teammates in MLB history.
MLB playoffs 2021 - Dynamic duo of Jose Altuve and Carlos Correa lead Houston Astros to ALCS Game 1 victory over Boston Red Sox
Astros come out on top in the series opener despite Kiké Hernández's display of October magic.
Altuve's costly error allows Red Sox to score
The Red Sox bring home a run as Jose Altuve has the ball bounce between his legs on what could have been an inning-ending double play.