TALLAHASSEE, Fla. -- There weren't many mock drafts that pegged EJ Manuel as the top quarterback available, but Jimbo Fisher had a hunch his guy would impress a few teams.

Manuel's athleticism made him a popular prospect for teams looking to exploit the option offense, and his strong arm and experience in Fisher's pro-style scheme made him a viable option in more traditional sets. In the end, that was enough to convince the Buffalo Bills to take Manuel with the 16th overall selection in Thursday's NFL draft -- the first quarterback taken.

"You think about the journey, when I was a little kid, the ups and down," Manuel said after the selection. "I'm just so happy."

Manuel's emotions were held in check throughout a rocky 2012 season in which he led Florida State to its first ACC championship in seven years. Throughout the season, Manuel's mother was battling breast cancer, missing several of his games late in the season, but she was on hand Thursday in New York as NFL commissioner Roger Goodell announced his name.

"I knew she was doing what she had to do to get better," Manuel said before the draft. "Football is a special part of my life, but having my mom for a lot longer, that's what's really important to me. I'm just happy she'll be there."

Manuel's surprising early selection is another boon for Fisher, too, who has become a guru for creating NFL quarterbacks. Manuel's predecessor, Christian Ponder, went 12th overall in the 2011 draft, and former protege at LSU, JaMarcus Russell, was a top overall selection in 2007.

"I'm extremely happy for EJ," Fisher said in a statement released by the school. “He’s a tremendous young man who has been a great representative of Florida State University. He’s worked extremely hard to get to this goal. He’s one of the main reasons that this program has been able to get back to national prominence because of the sacrifices he’s made through his career as well as his development as a player. I’m extremely happy for him and his family. This couldn’t have happen to a better group of people.”

Florida State's return to national prominence was on display throughout the first round of Thursday's draft, even after Manuel was selected.

Defensive tackle Bjoern Werner went 25th overall to the Indianapolis Colts, while the Minnesota Vikings took cornerback Xavier Rhodes with the 26th pick. Both players were juniors who departed FSU a year early.

Werner was pegged as a potential top-five selection late in the season after leading the ACC with 13 sacks, but his stock dipped slightly following an underwhelming performance at the combine.

Rhodes, who came to FSU as a wide receiver before Fisher convinced him to switch to cornerback, might have been a first-round pick a year ago had a bowl-game injury not derailed his plans. He returned for 2012 and helped Florida State's secondary to a No. 1 ranking in the nation in pass defense.

"We were laughing about the day when he didn't want to move over to corner," Fisher said. "He was mad at me for a couple of months. But it's funny how you go back and reminisce when things work out like that."

The three first-round selections were the most for Florida State since 2006, when four Seminoles were taken. They had just three first rounders in the six drafts since.

FSU figures to have at least two more players go in tonight's second round. Right tackle Menelik Watson and defensive end Cornelius Carradine are widely projected as early second-round talent.

As many as a half-dozen more Florida State players could fill out the later rounds of the draft, including fullback Lonnie Pryor, linebacker Vince Williams, kicker Dustin Hopkins and defensive end Brandon Jenkins.

That would mark a massive shift in Florida State's NFL prospects after a dry spell in recent years. FSU has had just 11 players selected in all in the last four drafts prior to this year.

"Hopefully we can do that every year as we establish ourselves as a program," Fisher said. "We've revamped the type of recruiting we're doing and identified certain types of athletes we thought were difference makers and great kids. We've come a long way."