Multiple South African record holder Dominique Scott-Efurd will lead the charge on Thursday when she opens the team's campaign at the IAAF World Indoor Championships in Birmingham, England.
The US-based distance runner, who participated at the 2016 Olympic Games in Rio, will line up in the 3 000m Women's race, taking place at 10.15pm (SA time) in the evening session on Day 1 of the four-day event.
The six-member national team will be eager to shine on Friday, with the Long Jump men's trio of world champion Luvo Manyonga, Ruswahl Samaai, and wild card entry Khotso Mokoena, turning out in a straight final.
The national team will aim to return to the podium for the first time in eight years, following a lengthy medal drought in the indoor format.
Former Long Jump champion Mokoena was the last South African to return home with a medal from the global indoor championships, when he earned silver at the 2010 edition in Doha.
Carina Horn will be chasing a place in the 60m women's battle, while Antonio Alkana will close out the South African campaign in the 60m men's Hurdles over the weekend.
The majority of the South African team will then return home to compete in the second and third legs of the inaugural Athletix Grand Prix series, which take place in Tshwane and Paarl on 8 and 22 March respectively.