The brother of Denver Broncos quarterback Joe, Flacco hit Chris Clark with a 12-yard scoring pass four minutes into the game, then hit Leatherbury with two scoring passes less than a minute apart as the Tigers staked a 21-0 lead after one quarter.
After Jared Cooper scored from 3-yards out for Bucknell's only points, Leatherbury pulled in passes from 2- and 45-yards out to make it 42-7 at the break.
Towson checked Bucknell on 18 yards of offense in the first quarter and the Bison trailed 28-0 before their offense ventured past midfield.
Flacco was 16 of 22 for 203 yards. Leatherbury's five touchdown catches ties a single-game school record set by Andrae Brown in 2005.
Domani Jackson, No. 5 recruit in 2022 class, commits to USC
Five-star cornerback Domani Jackson announced his commitment to USC on Saturday, choosing the Trojans over Arizona State, Clemson, Michigan and Ohio State.
Notre Dame placed on probation for one year
Tom VanHaaren breaks down the recruiting violations at Notre Dame.
New South Carolina Gamecocks coach Shane Beamer completes coaching staff
New South Carolina football coach Shane Beamer has made the final hires for his on-field staff.
New Tennessee Volunteers AD Danny White embracing rebuild, plans to hire new football coach quickly
Danny White is embracing the opportunity Tennessee is giving him to rebuild a Power 5 program, and not even the prospect of potential NCAA punishment deterred him from taking the athletic director job.
Three QBs from College Football Playoff among 131 players on official early entry NFL draft list
Ohio State junior quarterback Justin Fields is among 98 players granted special eligibility by the NFL into the league's draft, while national championship-winning QBs Mac Jones and Trevor Lawrence are among another 30.
Ohio State Buckeyes coach Ryan Day encouraged by returning players who put off NFL dreams
Despite several underclassmen leaving early, Ohio State coach Ryan Day said he is encouraged by the large number of players who decided to return for the 2021 season.