Bayer Leverkusen LEV v |  Rangers RAN | Postponed | BayArena, Germany | N/A |
| Bayer Leverkusen lead 3-1 on aggregate |
Getafe GET v |  Internazionale INT | Postponed | Coliseum Alfonso Pérez, Spain | N/A |
| Internazionale win on away goals |
Shakhtar Donetsk SHAK v |  VfL Wolfsburg WOLF | Postponed | Metalist Stadium, Ukraine | N/A |
| Shakhtar Donetsk lead 2-1 on aggregate |
Wolverhampton Wanderers WOLV v |  Olympiakos OLY | Postponed | Molineux Stadium, England | N/A |
| Olympiakos win on away goals |
AS Roma ROMA v |  Sevilla FC SEV | Postponed | Olimpico, Italy | N/A |
| Sevilla FC win on away goals |
FC Basel BAS v |  Eintracht Frankfurt EINF | Postponed | St. Jakob-Park | N/A |
| FC Basel lead 3-0 on aggregate |
FC Copenhagen COP v |  Istanbul Basaksehir IST | Postponed | Telia Parken, Gelsenkirchen | N/A |
| Istanbul Basaksehir advance 1-0 on aggregate |
Manchester United MAN v |  LASK Linz LAS | Postponed | Old Trafford, England | N/A |
| Manchester United lead 5-0 on aggregate |