Ajax Amsterdam AJA 2 - 1 |  Lille LILL | FT | Johan Cruijff Arena, Netherlands | N/A |
| Ajax Amsterdam advance 4-2 on aggregate |
Arsenal ARS 3 - 2 |  Benfica BEN | FT | Georgios Karaiskakis Stadium, Athens, Greece | N/A |
| Arsenal advance 4-3 on aggregate |
Napoli NAP 2 - 1 |  Granada GCF | FT | Diego Armando Maradona, Italy | N/A |
| Granada advance 3-2 on aggregate |
Rangers RAN 5 - 2 |  Antwerp ANT | FT | Ibrox Stadium, Scotland | N/A |
| Rangers advance 9-5 on aggregate |
Shakhtar Donetsk SHK 1 - 0 |  Maccabi Tel-Aviv MTA | FT | Kiev Olympic Stadium, Kiev, Ukraine | N/A |
| Shakhtar Donetsk advance 3-0 on aggregate |
TSG Hoffenheim HOF 0 - 2 |  Molde MOL | FT | PreZero Arena | N/A |
| Molde advance 5-3 on aggregate |
Villarreal VILL 2 - 1 |  FC Salzburg SALZ | FT | Estadio de la Cerámica, Spain | N/A |
| Villarreal advance 4-1 on aggregate |
AC Milan MIL 1 - 1 |  Red Star Belgrade RSB | FT | Giuseppe Meazza | N/A |
| AC Milan win on away goals |
AS Roma ROMA 3 - 1 |  Braga BRAG | FT | Olimpico, Italy | N/A |
| AS Roma advance 5-1 on aggregate |
Bayer Leverkusen LEV 0 - 2 |  Young Boys BOY | FT | BayArena, Germany | N/A |
| Young Boys advance 6-3 on aggregate |
Club Brugge BRUG 0 - 1 |  Dynamo Kiev KIEV | FT | Jan Breydelstadion | N/A |
| Dynamo Kiev advance 2-1 on aggregate |
Dinamo Zagreb ZAG 1 - 0 |  Krasnodar FCK | FT | Maksimir | N/A |
| Dinamo Zagreb advance 4-2 on aggregate |
Leicester City LEI 0 - 2 |  Slavia Prague SLP | FT | King Power Stadium | N/A |
| Slavia Prague advance 2-0 on aggregate |
Manchester United MAN 0 - 0 |  Real Sociedad RSO | FT | Old Trafford, England | N/A |
| Manchester United advance 4-0 on aggregate |
PSV Eindhoven PSV 2 - 1 |  Olympiakos OLY | FT | Philips Stadion, Netherlands | N/A |
| Olympiakos advance 5-4 on aggregate |