- Andrej Kramaric (28')
- Nathan Broadhead (90'+3')
Wales played their first match since their talisman Gareth Bale retired from the sport in January after making a record 111 appearances.
Croatia broke the deadlock in the 28th minute when Kramaric managed to break free from his marker to rifle in the ball from outside the box.
In the second half Wales tried to dominate proceedings by speeding up the game and testing the Croatia defence.
Second-half substitute Broadhead rescued a point for the visitors three minutes into stoppage time when he steered the ball home at the far post after a long throw in.
Turkey beat Armenia 2-1 in the other Group D match earlier on Saturday.
- João Pinheiro