Rutherford didn't miss a free throw (8 of 8) and Greene was 8-of-10 shooting with a game-high 12 rebounds and four blocks. Evan Leonard added 15 points and Eyassu Worku had 11 for UC Irvine (13-9, 5-1 Big West Conference), which shot 57% (32 of 56) from the floor.
The Anteaters had a double-digit lead midway through the first half and built a 54-34 halftime advantage.
Cal State Fullerton returns home to face UC Riverside on Wednesday. UC Irvine hosts UC Davis on Thursday.
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