Pittsburgh Pirates (33-28, second in the NL Central) vs. Houston Astros (27-35, fourth in the AL West)

Houston; Wednesday, 8:10 p.m. EDT

PITCHING PROBABLES: Pirates: Paul Skenes (6-5, 2.89 ERA, 0.86 WHIP, 75 strikeouts); Astros: Spencer Arrighetti (7-1, 1.34 ERA, 1.13 WHIP, 43 strikeouts)

LINE: Pirates -157, Astros +130; over/under is 7 1/2 runs

BOTTOM LINE: The Pittsburgh Pirates take on the Houston Astros after Jake Mangum had four hits on Tuesday in a 10-6 win over the Astros.

Houston has a 13-17 record at home and a 27-35 record overall. The Astros have the fifth-ranked team batting average in the AL at .243.

Pittsburgh has a 15-13 record in road games and a 33-28 record overall. The Pirates have the third-ranked team batting average in the NL at .255.

Wednesday's game is the second time these teams square off this season.

TOP PERFORMERS: Isaac Paredes has 10 doubles, six home runs and 24 RBI for the Astros. Yordan Alvarez is 11 for 35 with a double and six home runs over the last 10 games.

Oneil Cruz has 10 doubles and 14 home runs for the Pirates. Spencer Horwitz is 12 for 38 with a double and three home runs over the last 10 games.

LAST 10 GAMES: Astros: 6-4, .227 batting average, 3.60 ERA, outscored opponents by 17 runs

Pirates: 7-3, .271 batting average, 4.35 ERA, outscored opponents by 13 runs

INJURIES: Astros: Braden Shewmake: 10-Day IL (groin), Joey Loperfido: 10-Day IL (quadricep), Carlos Correa: 60-Day IL (ankle), Lance McCullers: 15-Day IL (shoulder), Bennett Sousa: 15-Day IL (elbow), Yainer Diaz: 10-Day IL (abdominal), Jose Altuve: 10-Day IL (side), Hunter Brown: 60-Day IL (shoulder), Cristian Javier: 60-Day IL (shoulder), Brandon Walter: 60-Day IL (elbow), Ronel Blanco: 60-Day IL (elbow), Hayden Wesneski: 60-Day IL (elbow)

Pirates: Konnor Griffin: 10-Day IL (flexor tendon), Chris Devenski: 15-Day IL (illness), Joey Bart: 10-Day IL (foot infection)

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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.