San Francisco49ers
- 6-8
- 4th in NFC West
San Francisco 49ers Schedule 2021
| Postseason | |||||||||
| WK | DATE | OPPONENT | RESULT | W-L | Hi Pass | Hi Rush | Hi Rec | ||
| WC | Sun, 16 Jan | W23-17 | 10-7 | Garoppolo 172 | Mitchell 96 | Aiyuk 66 | |||
| DIV | Sun, 23 Jan | W13-10 | 10-7 | Garoppolo 131 | Mitchell 53 | Kittle 63 | |||
| CONF | Sun, 30 Jan | L20-17 | 10-7 | Garoppolo 232 | Samuel Sr. 26 | Samuel Sr. 72 | |||
| Regular Season | |||||||||
| WK | DATE | OPPONENT | RESULT | W-L | Hi Pass | Hi Rush | Hi Rec | ||
| 1 | Sun, 12 Sep | W41-33 | 1-0 | Garoppolo 314 | Mitchell 104 | Samuel Sr. 189 | |||
| 2 | Sun, 19 Sep | W17-11 | 2-0 | Garoppolo 189 | Mitchell 42 | Samuel Sr. 93 | |||
| 3 | Mon, 27 Sep | L30-28 | 2-1 | Garoppolo 257 | Sermon 31 | Kittle 92 | |||
| 4 | Sun, 3 Oct | L28-21 | 2-2 | Garoppolo 165 | Sermon 89 | Samuel Sr. 156 | |||
| 5 | Sun, 10 Oct | L17-10 | 2-3 | Lance 192 | Lance 89 | Samuel Sr. 58 | |||
| 6 | BYE WEEK | ||||||||
| 7 | Mon, 25 Oct | L30-18 | 2-4 | Garoppolo 181 | Mitchell 107 | Samuel Sr. 100 | |||
| 8 | Sun, 31 Oct | W33-22 | 3-4 | Garoppolo 322 | Mitchell 137 | Samuel Sr. 171 | |||
| 9 | Sun, 7 Nov | L31-17 | 3-5 | Garoppolo 326 | Mitchell 36 | Kittle 101 | |||
| 10 | Tue, 16 Nov | W31-10 | 4-5 | Garoppolo 182 | Mitchell 91 | Samuel Sr. 97 | |||
| 11 | Sun, 21 Nov | W30-10 | 5-5 | Garoppolo 176 | Samuel Sr. 79 | Aiyuk 85 | |||
| 12 | Sun, 28 Nov | W34-26 | 6-5 | Garoppolo 230 | Mitchell 133 | Aiyuk 91 | |||
| 13 | Sun, 5 Dec | L30-23 | 6-6 | Garoppolo 299 | Mitchell 66 | Kittle 181 | |||
| 14 | Sun, 12 Dec | W26-23 OT | 7-6 | Garoppolo 296 | Wilson Jr. 56 | Kittle 151 | |||
| 15 | Sun, 19 Dec | W31-13 | 8-6 | Garoppolo 235 | Wilson Jr. 110 | Kittle 93 | |||
| 16 | Fri, 24 Dec | L20-17 | 8-7 | Garoppolo 322 | Wilson Jr. 45 | Samuel Sr. 159 | |||
| 17 | Sun, 2 Jan | W23-7 | 9-7 | Lance 249 | Mitchell 119 | Aiyuk 94 | |||
| 18 | Sun, 9 Jan | W27-24 OT | 10-7 | Garoppolo 316 | Mitchell 85 | Aiyuk 107 | |||
| Preseason | |||||||||
| WK | DATE | OPPONENT | RESULT | W-L | Hi Pass | Hi Rush | Hi Rec | ||
| 1 | Sun, 15 Aug | L19-16 | 0-1 | Lance 128 | Hasty 63 | Sherfield Sr. 80 | |||
| 2 | Mon, 23 Aug | W15-10 | 1-1 | Lance 102 | Gallman 72 | Sherfield Sr. 50 | |||
| 3 | Sun, 29 Aug | W34-10 | 2-1 | Garoppolo 64 | Gallman 60 | Sherfield Sr. 26 | |||