Vanderbilt Schedule 2021
| Regular Season | |||||||
| DATE | OPPONENT | RESULT | W-L (CONF) | HI PASS | HI RUSH | HI REC | |
| Sun, 5 Sep | L23-3 | 0-1 (0-0) | Seals 195 | Davis 58 | Sheppard 84 | ||
| Sun, 12 Sep | W24-21 | 1-1 (0-0) | Seals 238 | Davis 77 | Pierce Jr. 76 | ||
| Sun, 19 Sep | L41-23 | 1-2 (0-0) | Seals 120 | Griffin 107 | Pierce Jr. 52 | ||
| Sat, 25 Sep | L62-0 | 1-3 (0-1) | Wright 16 | Wright 41 | Johnson 10 | ||
| Sun, 3 Oct | W30-28 | 2-3 (0-1) | Seals 333 | Griffin 77 | Sheppard 119 | ||
| Sat, 9 Oct | L42-0 | 2-4 (0-2) | Seals 192 | Smith 75 | Johnson 49 | ||
| Sat, 16 Oct | L21-20 | 2-5 (0-3) | Wright 206 | Griffin 57 | Sheppard 120 | ||
| Sat, 23 Oct | L45-6 | 2-6 (0-4) | Wright 122 | Griffin 12 | Boddie Jr. 69 | ||
| Sat, 30 Oct | L37-28 | 2-7 (0-5) | Wright 122 | Wright 152 | Pierce Jr. 54 | ||
| Sun, 14 Nov | L34-17 | 2-8 (0-6) | Seals 87 | Smith 84 | Pierce Jr. 69 | ||
| Sun, 21 Nov | L31-17 | 2-9 (0-7) | Wright 241 | Griffin 117 | Pierce Jr. 113 | ||
| Sat, 27 Nov | L45-21 | 2-10 (0-8) | Wright 198 | Griffin 104 | Sheppard 98 | ||
