- Rodrygo (24', 53')
- Raphinha (47')
- Neymar (61', 90'+3')
- Víctor Abrego (78')
The 31-year-old Neymar, who recently joined Saudi side Al-Hilal, bounced back after missing a penalty in the first half, scoring two goals in the 61st and 93rd minutes to become the country's all-time top scorer with 79 goals.
Raphinha, who replaced Antony in the Brazilian squad, scored to make it 2-0 in the opening seconds of the second half with a shot at the far post after picking up Neymar's pass in the edge of the box.
Bolivia got their consolation goal through Victor Abrego's powerful shot in the 78th minute.
Brazil will look to continue their good form when they visit Peru on Tuesday in the second round of CONMEBOL qualifiers.
- Juan Gabriel Benítez