The Titans used a 7-0 surge to pull to 51-50 with 1:06 to play, but the Gauchos made four free throws and led 55-51 with six seconds left.
UC Santa Barbara (20-10, 9-6 Big West Conference) has won four of its last five games. Cal State Fullerton (10-20, 5-10) has lost five of six.
Devearl Ramsey added 13 points for the Gauchos.
Cal State Fullerton hosts Long Beach State on Saturday. UC Santa Barbara plays at home Saturday against Cal Poly.
For more AP college basketball coverage: https://apnews.com/Collegebasketball and http://twitter.com/AP-Top25
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