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7 Jan
Isaac Guerendo
RB
Status
Questionable
Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The Athletic reports.
6 Jan
Christian McCaffrey
RB
Status
Injured reserve
McCaffrey (knee) said Monday he's "definitely close" to 100 percent healthy and could have played had the 49ers qualified for the playoffs, Nick Wagoner of ESPN.com reports.
Deebo Samuel Sr.
WR
Status
Questionable
Brock Purdy
QB
Status
Questionable
Deommodore Lenoir
CB
Status
Questionable
Robert Beal Jr.
DE
Status
Questionable
Colton McKivitz
OT
Status
Questionable
5 Jan
Chris Conley
WR
Status
Questionable
Conley (elbow) is questionable to return to Sunday's contest against the Cardinals, Jennifer Lee Chan of NBC Sports Bay Area reports.
Renardo Green
CB
Status
Questionable
Green has been deemed questionable to return to Sunday's Week 18 matchup against Arizona due to a groin injury, Lindsey Pallares of the 49ers' official site reports.
Talanoa Hufanga
S
Status
Questionable
Hufanga was diagnosed with a concussion during Sunday's game against the Cardinals and will not return, Nick Wagoner of ESPN.com reports.
Malik Mustapha
S
Status
Questionable
Mustapha (knee) has been ruled out for the rest of Sunday's contest versus the Cardinals, Matt Maiocco of NBC Sports Bay Area reports.
Spencer Burford
OT
Status
Injured reserve
The 49ers placed Burford (calf) on injured reserve Saturday.
Demetrius Flannigan-Fowles
LB
Status
Injured reserve
Flannigan-Fowles (calf) was placed on the 49ers' injured reserve Saturday.
31 Dec
Dre Greenlaw
LB
Status
Injured reserve
The 49ers moved Greenlaw (calf) to IR on Tuesday.
30 Dec
Aaron Banks
G
Status
Injured reserve
The 49ers placed Banks (knee) on injured reserve Monday.
26 Dec
Trent Williams
OT
Status
Injured reserve
The 49ers placed Williams (ankle) on injured reserve Thursday.
Jaylon Moore
G
Status
Injured reserve
The 49ers placed Moore (quadriceps) on injured reserve Wednesday.
13 Dec
Ben Bartch
G
Status
Injured reserve
Bartch (ankle) was placed on injured reserve Thursday, Matt Barrows of The Athletic reports.
8 Dec
George Odum
S
Status
Injured reserve
The 49ers placed Odum (knee) on injured reserve Saturday, Matt Barrows of The Athletic reports.
7 Dec
Jordan Mason
RB
Status
Injured reserve
Mason (ankle) was officially placed on injured reserve Saturday, Adam Schefter of ESPN reports.
4 Dec
Kevin Givens
DT
Status
Injured reserve
Givens (pectoral) was placed on injured reserve Wednesday.
25 Nov
Jon Feliciano
G
Status
Injured reserve
Feliciano (knee) will remain on injured reserve for the remainder of the season, Matt Barrows of The Athletic reports.
17 Nov
Darrell Luter Jr.
CB
Status
Injured reserve
Luter (pelvis) was placed on the 49ers' injured reserve Saturday, Matt Barrows of The Athletic reports.
Mitch Wishnowsky
P
Status
Injured reserve
The 49ers placed Wishnowsky (back) on injured reserve Saturday, Matt Barrows of The Athletic reports.
15 Nov
Brandon Aiyuk
WR
Status
Injured reserve
Aiyuk had surgery to repair the ACL and other damage in is right knee earlier this week, David Lombardi of The San Francisco Standard reports.