San Francisco49ers
- 6-8
- 4th in NFC West
San Francisco 49ers Schedule 2022
| Postseason | |||||||||
| WK | DATE | OPPONENT | RESULT | W-L | Hi Pass | Hi Rush | Hi Rec | ||
| WC | Sat, 14 Jan | W41-23 | 13-4 | Purdy 332 | McCaffrey 119 | Samuel Sr. 133 | |||
| DIV | Sun, 22 Jan | W19-12 | 13-4 | Purdy 214 | Mitchell 51 | Kittle 95 | |||
| CONF | Sun, 29 Jan | L31-7 | 13-4 | Johnson 74 | McCaffrey 84 | Samuel Sr. 33 | |||
| Regular Season | |||||||||
| WK | DATE | OPPONENT | RESULT | W-L | Hi Pass | Hi Rush | Hi Rec | ||
| 1 | Sun, 11 Sep | L19-10 | 0-1 | Lance 164 | Lance 54 | Jennings 62 | |||
| 2 | Sun, 18 Sep | W27-7 | 1-1 | Garoppolo 154 | Wilson Jr. 84 | Aiyuk 63 | |||
| 3 | Mon, 26 Sep | L11-10 | 1-2 | Garoppolo 211 | Wilson Jr. 75 | Samuel Sr. 73 | |||
| 4 | Tue, 4 Oct | W24-9 | 2-2 | Garoppolo 239 | Wilson Jr. 74 | Samuel Sr. 115 | |||
| 5 | Sun, 9 Oct | W37-15 | 3-2 | Garoppolo 253 | Wilson Jr. 120 | Aiyuk 58 | |||
| 6 | Sun, 16 Oct | L28-14 | 3-3 | Garoppolo 296 | Wilson Jr. 25 | Aiyuk 83 | |||
| 7 | Sun, 23 Oct | L44-23 | 3-4 | Garoppolo 303 | Wilson Jr. 54 | Kittle 98 | |||
| 8 | Sun, 30 Oct | W31-14 | 4-4 | Garoppolo 235 | McCaffrey 94 | Aiyuk 81 | |||
| 9 | BYE WEEK | ||||||||
| 10 | Mon, 14 Nov | W22-16 | 5-4 | Garoppolo 240 | Mitchell 89 | Aiyuk 84 | |||
| 11 | Tue, 22 Nov | W38-10 | 6-4 | Garoppolo 228 | Mitchell 59 | Kittle 84 | |||
| 12 | Sun, 27 Nov | W13-0 | 7-4 | Garoppolo 222 | Mitchell 35 | Aiyuk 65 | |||
| 13 | Sun, 4 Dec | W33-17 | 8-4 | Purdy 210 | McCaffrey 66 | McCaffrey 80 | |||
| 14 | Sun, 11 Dec | W35-7 | 9-4 | Purdy 185 | McCaffrey 119 | Aiyuk 57 | |||
| 15 | Fri, 16 Dec | W21-13 | 10-4 | Purdy 217 | McCaffrey 108 | Kittle 93 | |||
| 16 | Sat, 24 Dec | W37-20 | 11-4 | Purdy 234 | McCloud III 71 | Kittle 120 | |||
| 17 | Sun, 1 Jan | W37-34 OT | 12-4 | Purdy 284 | McCaffrey 121 | Aiyuk 101 | |||
| 18 | Sun, 8 Jan | W38-13 | 13-4 | Purdy 178 | Mitchell 55 | Aiyuk 59 | |||
| Preseason | |||||||||
| WK | DATE | OPPONENT | RESULT | W-L | Hi Pass | Hi Rush | Hi Rec | ||
| 1 | Sat, 13 Aug | W28-21 | 1-0 | Sudfeld 103 | Hasty 36 | Gray 99 | |||
| 2 | Sun, 21 Aug | W17-7 | 2-0 | Purdy 128 | Mason 57 | Hudson 43 | |||
| 3 | Fri, 26 Aug | L17-0 | 2-1 | Purdy 182 | Sermon 20 | Dwelley 42 | |||