Monaco regained their three-point advantage at the Ligue 1 summit thanks to a 3-0 victory over Nancy.
With title rivals Paris Saint-Germain thrashing Bastia 5-0 earlier on Saturday to move temporarily level on points, Leonardo Jardim's men had to respond.
And an own goal from Tobias Badila and strikes from Bernando Silva and Thomas Lemar saw them bounce back from their Champions League defeat against Juventus in midweek and strengthen their chances of securing their first title since 2000.
Nancy remain 19th, three points adrift of safety.
There were no signs of a European hangover at Stade Marcel Picot as the Ligue 1 leaders raced into a 1-0 lead after three minutes when Valere Germain's cross deflected off the foot of Nancy defender Badila and wrong-footed Guy N'Dy Assembe.
Radamel Falcao almost doubled their lead but his shot was comfortably saved by Assembe in the Nancy goal.
Nancy's Youssouf Hadji should have done better as he failed to get his header on target after Antony Robic's cross but the visitors stretched their lead further just before half-time. A swift counter-attack saw Lemar's cross meet the head of Silva, who nodded into the bottom corner.
Tiemoue Bakayoko missed a glorious chance to make it three but Lemar got on the scoresheet from close range in the 86th minute.
Kylian Mbappe came close to adding another goal to his impressive season as Monaco comfortably claimed all three points.