| MLB First Round Draft Picks - St. Louis Cardinals | ||||
| SEASON | PLAYER | POS | SCHOOL/HOMETOWN | PICK |
| 2016 | Dakota Hudson | RHP | Mississippi State | 34 |
| 2016 | Dylan Carlson | 1B | Elk Grove (California) HS | 33 |
| 2016 | Delvin Perez | SS | International Baseball Academy (Puerto Rico) | 23 |
| 2015 | Nick Plummer | OF | Brother Rice HS (Lathrup Village, Mich.) | 23 |
| 2014 | Luke Weaver | RHP | Florida State | 27 |
| 2013 | Rob Kaminsky | LHP | Saint Joseph Regional High School, Montvale, | 28 |
| 2013 | Marco Gonzales | LHP | Gonzaga | 19 |
| 2012 | James Ramsey | OF | Florida State | 23 |
| 2012 | Michael Wacha | RHP | Texas A&M | 19 |
| 2011 | Kolten Wong | 2B | Hawaii | 22 |
| 2010 | Tyrell Jenkins | RHP | Henderson (Tex.) High School | 50 |
| 2010 | Seth Blair | RHP | Arizona State | 46 |
| 2010 | Zack Cox | 3B | Arkansas | 25 |
| 2009 | Shelby Miller | RHP | Brownwood (Texas) HS | 19 |
| 2008 | Brett Wallace | 3B | Arizona State | 13 |
| 2007 | Peter Kozma | SS | Owasso (Okla.) HS | 18 |
| 2006 | Adam Ottavino | RHP | Northeastern | 30 |
| 2005 | James Greene | SS | Georgia Tech | 30 |
| 2005 | Colby Rasmus | CF | Russell County HS (AL) | 28 |
| 2004 | Chris Lambert | RHP | Boston College | 19 |
| 2003 | Daric Barton | C | Marina HS (CA) | 28 |
| 2001 | Justin Pope | RHP | U. of Central Florida | 28 |
| 2000 | Blake Williams | RHP | San Marcos, TX | 24 |
| 2000 | Shaun Boyd | 2B | Oceanside, CA | 13 |
| 1999 | Chance Caple | RHP | Texas A&M U. | 30 |
| 1998 | J.D. Drew | OF | No School | 5 |
| 1997 | Adam Kennedy | SS | Cal State Northridge | 20 |
| 1996 | Braden Looper | RHP | Wichita State U | 3 |
| 1995 | Matt Morris | RHP | Seton Hall U | 12 |
| 1994 | Bret Wagner | LHP | Wake Forest U | 19 |
| 1993 | Alan Benes | RHP | Creighton U | 16 |
| 1992 | Jonathan Lowe | RHP | Arizona State U | 15 |
| 1991 | Brian Barber | RHP | Orlando, FL | 22 |
| 1991 | Allen Watson | LHP | New York Institute | 21 |
| 1991 | Dmitri Young | SS | Camarillo, CA | 4 |
| 1990 | Aaron Holbert | SS | Long Beach, CA | 18 |
| 1990 | Donovan Osborne | LHP | U of Nevada | 13 |
| 1989 | Paul Coleman | OF | Frankston, TX | 6 |
| 1988 | Brad DuVall | RHP | Virginia Tech | 23 |
| 1988 | John Ericks | RHP | U of Illinois | 22 |
| 1987 | Cris Carpenter | RHP | U of Georgia | 14 |
| 1986 | Luis Alicea | 2B | Florida State U | 23 |
| 1985 | Joe Magrane | LHP | U of Arizona | 18 |
| 1984 | Mike Dunne | RHP | Bradley U | 7 |
| 1983 | Jim Lindeman | 3B | Bradley U | 24 |
| 1982 | Todd Worrell | RHP | Biola College | 21 |
| 1981 | Bobby Meacham | SS | San Diego State U | 8 |
| 1980 | Don Collins | RHP | Newport News, VA | 15 |
| 1979 | Andy Van Slyke | OF | New Hartford, NY | 6 |
| 1978 | Robert Hicks | 1B | Pensacola, FL | 15 |
| 1977 | Terry Kennedy | C | Florida State U | 6 |
| 1976 | Leon Durham | 1B | Cincinnati, OH | 15 |
| 1975 | David Johnson | LHP | Gaylord, MI | 16 |
| 1974 | Garry Templeton | SS | Santa Ana, CA | 13 |
| 1973 | Joe Edelen | 3B-RH | Gracemont, OK | 12 |
| 1972 | Dan Larson | RHP | Alhambra, CA | 21 |
| 1971 | Ed Kurpiel | 1B-LH | Hollis, NY | 8 |
| 1970 | Jim Browning | RHP | Gadsden, AL | 11 |
| 1969 | Charles Minott | LHP | Covina, CA | 20 |
| 1968 | James Hairston | OF | Dayton, OH | 19 |
| 1967 | Ted Simmons | C | Southfield, MI | 10 |
| 1966 | Leron Lee | OF | Sacramento, CA | 7 |
| 1965 | Joe DiFabio | RHP | Delta State U | 20 |