| 1921 MLB Leaders | ||
| 1921 American League Standings | |||||||||
| TEAM | W | L | PCT | GB | HOME | ROAD | RS | RA | DIFF |
| *-New York | 98 | 55 | .641 | -- | -- | -- | 948 | 708 | +240 |
| Cleveland | 94 | 60 | .610 | 4.5 | -- | -- | 925 | 712 | +213 |
| St. Louis | 81 | 73 | .526 | 17.5 | -- | -- | 835 | 845 | -10 |
| Washington | 80 | 73 | .519 | 18 | -- | -- | 704 | 738 | -34 |
| Boston | 75 | 79 | .487 | 23.5 | -- | -- | 668 | 696 | -28 |
| Detroit | 71 | 82 | .461 | 27 | -- | -- | 883 | 852 | +31 |
| Chicago | 62 | 92 | .403 | 36.5 | -- | -- | 683 | 858 | -175 |
| Philadelphia | 53 | 100 | .342 | 45 | -- | -- | 657 | 894 | -237 |
| 1921 National League Standings | |||||||||
| TEAM | W | L | PCT | GB | HOME | ROAD | RS | RA | DIFF |
| *-New York | 94 | 59 | .614 | -- | -- | -- | 840 | 637 | +203 |
| Pittsburgh | 90 | 63 | .584 | 4 | -- | -- | 692 | 595 | +97 |
| St. Louis | 87 | 66 | .565 | 7 | -- | -- | 809 | 681 | +128 |
| Boston | 79 | 74 | .516 | 15 | -- | -- | 721 | 697 | +24 |
| Brooklyn | 77 | 75 | .507 | 16.5 | -- | -- | 667 | 681 | -14 |
| Cincinnati | 70 | 83 | .458 | 24 | -- | -- | 618 | 649 | -31 |
| Chicago | 64 | 89 | .418 | 30 | -- | -- | 668 | 773 | -105 |
| Philadelphia | 51 | 103 | .331 | 43.5 | -- | -- | 617 | 919 | -302 |
| 1921 All-Star Results | |||||||||
| No results available. | |||||||||
| Rosters | Complete Results | |||||||||
| 1921 Postseason Results | ||
| ROUND | OUTCOME | RESULT |
| World Series | New York Giants defeated New York Yankees | 5-3 |
| Complete Results | ||
| 1921 Award Winners | ||
| No award winners. | ||
| Complete Results |
| 1921 Draft Picks | |||
| No picks available. | |||
| Complete Results |
| 1921 No-Hitters | ||||||
| No no-hitters. | ||||||
| Complete Results |