| 2021 MLB Leaders | ||
| 2021 American League Standings | |||||||||
| EAST | W | L | PCT | GB | HOME | ROAD | RS | RA | DIFF |
| *-Tampa Bay | 100 | 62 | .617 | -- | 52-29 | 48-33 | 857 | 651 | +206 |
| y-Boston | 92 | 70 | .568 | 8 | 49-32 | 43-38 | 829 | 749 | +80 |
| y-NY Yankees | 92 | 70 | .568 | 8 | 46-35 | 46-35 | 711 | 669 | +42 |
| e-Toronto | 91 | 71 | .562 | 9 | 47-33 | 44-38 | 846 | 663 | +183 |
| e-Baltimore | 52 | 110 | .321 | 48 | 27-54 | 25-56 | 659 | 956 | -297 |
| CENTRAL | W | L | PCT | GB | HOME | ROAD | RS | RA | DIFF |
| x-Chicago Sox | 93 | 69 | .574 | -- | 53-28 | 40-41 | 796 | 636 | +160 |
| e-Cleveland | 80 | 82 | .494 | 13 | 40-41 | 40-41 | 717 | 727 | -10 |
| e-Detroit | 77 | 85 | .475 | 16 | 42-39 | 35-46 | 697 | 756 | -59 |
| e-Kansas City | 74 | 88 | .457 | 19 | 39-42 | 35-46 | 686 | 788 | -102 |
| e-Minnesota | 73 | 89 | .451 | 20 | 38-43 | 35-46 | 729 | 834 | -105 |
| WEST | W | L | PCT | GB | HOME | ROAD | RS | RA | DIFF |
| x-Houston | 95 | 67 | .586 | -- | 51-30 | 44-37 | 863 | 658 | +205 |
| e-Seattle | 90 | 72 | .556 | 5 | 46-35 | 44-37 | 697 | 748 | -51 |
| e-Oakland | 86 | 76 | .531 | 9 | 43-38 | 43-38 | 743 | 687 | +56 |
| e-LA Angels | 77 | 85 | .475 | 18 | 40-42 | 37-43 | 723 | 804 | -81 |
| e-Texas | 60 | 102 | .370 | 35 | 36-45 | 24-57 | 625 | 815 | -190 |
| 2021 National League Standings | |||||||||
| EAST | W | L | PCT | GB | HOME | ROAD | RS | RA | DIFF |
| x-Atlanta | 88 | 73 | .547 | -- | 42-38 | 46-35 | 790 | 656 | +134 |
| e-Philadelphia | 82 | 80 | .506 | 6.5 | 47-34 | 35-46 | 734 | 745 | -11 |
| e-NY Mets | 77 | 85 | .475 | 11.5 | 47-34 | 30-51 | 636 | 668 | -32 |
| e-Miami | 67 | 95 | .414 | 21.5 | 42-39 | 25-56 | 623 | 701 | -78 |
| e-Washington | 65 | 97 | .401 | 23.5 | 35-46 | 30-51 | 724 | 820 | -96 |
| CENTRAL | W | L | PCT | GB | HOME | ROAD | RS | RA | DIFF |
| x-Milwaukee | 95 | 67 | .586 | -- | 45-36 | 50-31 | 738 | 623 | +115 |
| y-St. Louis | 90 | 72 | .556 | 5 | 45-36 | 45-36 | 706 | 672 | +34 |
| e-Cincinnati | 83 | 79 | .512 | 12 | 44-37 | 39-42 | 786 | 760 | +26 |
| e-Chicago Cubs | 71 | 91 | .438 | 24 | 39-42 | 32-49 | 705 | 839 | -134 |
| e-Pittsburgh | 61 | 101 | .377 | 34 | 37-44 | 24-57 | 609 | 833 | -224 |
| WEST | W | L | PCT | GB | HOME | ROAD | RS | RA | DIFF |
| *-San Francisco | 107 | 55 | .660 | -- | 54-27 | 53-28 | 804 | 594 | +210 |
| y-LA Dodgers | 106 | 56 | .654 | 1 | 58-23 | 48-33 | 830 | 561 | +269 |
| e-San Diego | 79 | 83 | .488 | 28 | 45-36 | 34-47 | 729 | 708 | +21 |
| e-Colorado | 74 | 87 | .460 | 32.5 | 48-33 | 26-54 | 739 | 796 | -57 |
| e-Arizona | 52 | 110 | .321 | 55 | 32-49 | 20-61 | 679 | 893 | -214 |
| 2021 All-Star Results | |||||||||
| No results available. | |||||||||
| Rosters | Complete Results | |||||||||
| 2021 Postseason Results | ||
| ROUND | OUTCOME | RESULT |
| World Series | Atlanta Braves defeated Houston Astros | 4-2 |
| League Championship Series | Atlanta Braves defeated Los Angeles Dodgers | 4-2 |
| League Championship Series | Houston Astros defeated Boston Red Sox | 4-2 |
| League Divisional Series | Boston Red Sox defeated Tampa Bay Rays | 3-1 |
| League Divisional Series | Atlanta Braves defeated Milwaukee Brewers | 3-1 |
| League Divisional Series | Houston Astros defeated Chicago White Sox | 3-1 |
| League Divisional Series | Los Angeles Dodgers defeated San Francisco Giants | 3-2 |
| Wild Card Game | Boston Red Sox defeated New York Yankees | 1-0 |
| Wild Card Game | Los Angeles Dodgers defeated St. Louis Cardinals | 1-0 |
| Complete Results | ||
| 2021 Award Winners | ||
| PLAYER | TEAM | AWARD |
| No award winners. | ||
| Complete Results | ||
| 2021 Draft Picks | |||
| No picks available. | |||
| Complete Results |
| 2021 No-Hitters | ||||||
| DATE | PITCHER | TEAM | OPPONENT | SCORE | LEAGUE | NOTES |
| 9/11/2021 | Josh Hader (1) | MIL | CLE | 3-0 | AL | Combined |
| 9/11/2021 | Corbin Burnes (8) | MIL | CLE | 3-0 | AL | Combined |
| 8/14/2021 | Tyler Gilbert | ARI | SD | 7-0 | NL | |
| 6/24/2021 | Craig Kimbrel (1) | CHC | LAD | 4-0 | NL | Combined |
| 6/24/2021 | Ryan Tepera (1) | CHC | LAD | 4-0 | NL | Combined |
| 6/24/2021 | Andrew Chafin (1) | CHC | LAD | 4-0 | NL | Combined |
| 6/24/2021 | Zach Davies (6) | CHC | LAD | 4-0 | NL | Combined |
| 5/19/2021 | Corey Kluber | NYY | TEX | 2-0 | AL | |
| 5/18/2021 | Spencer Turnbull | DET | SEA | 5-0 | AL | |
| 5/7/2021 | Wade Miley | CIN | CLE | 3-0 | AL | |
| 5/5/2021 | John Means | BAL | SEA | 6-0 | AL | |
| 4/14/2021 | Carlos Rodon | CHW | CLE | 8-0 | AL | |
| 4/9/2021 | Joe Musgrove | SD | TEX | 3-0 | AL | |
| Complete Results | ||||||