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Kyle Shanahan: We've put oursevles in a tough bind

High-scoring Bills return from their bye week to host inconsistent 49ers, losers of their past 2

San Francisco (5-6) at Buffalo (9-2)
Nov 27, 2025, 07:10 pm - AP

Season Leaders

SF
BUF
Passing Yards
Q
B. Purdy
SF

B. Purdy

202/306, 2613 YDS, 13 TD, 8 INT
J. Allen
BUF

J. Allen

217/339, 2543 YDS, 18 TD, 5 INT
Rushing Yards
J. Mason
SF

J. Mason

140 CAR, 711 YDS, 3 TD
J. Cook
BUF

J. Cook

137 CAR, 596 YDS, 10 TD
Receiving Yards
G. Kittle
SF

G. Kittle

49 REC, 642 YDS, 8 TD
K. Shakir
BUF

K. Shakir

56 REC, 599 YDS, 2 TD

Injury Report

San Francisco 49ers
Name, PosStatusEst. Return Date
Chris Conley
WR		QUESTIONABLE1 Dec
Brock Purdy
QB		QUESTIONABLE1 Dec
Renardo Green
CB		QUESTIONABLE1 Dec
Jacob Cowing
WR		QUESTIONABLE1 Dec
Dre Greenlaw
LB		PUP-R1 Dec
Buffalo Bills
Name, PosStatusEst. Return Date
Keon Coleman
WR		QUESTIONABLE1 Dec
Dalton Kincaid
TE		QUESTIONABLE1 Dec
DeWayne Carter
DT		IR-R1 Dec
Tylan Grable
OT		IR-R1 Dec
Matt Milano
LB		IR-R1 Dec
49ers Last 5
DATEOPPRESULT
11/24/24@GBL38-10
11/17/24vsSEAL20-17
11/10/24@TBW23-20
10/28/24vsDALW30-24
10/20/24vsKCL28-18
Bills Last 5
DATEOPPRESULT
11/17/24vsKCW30-21
11/10/24@INDW30-20
11/3/24vsMIAW30-27
10/27/24@SEAW31-10
10/20/24vsTENW34-10
Data is currently unavailable.