BuffaloSabres
- 47-23-8
- 1st in Atlantic Division
Buffalo Sabres Schedule 2021-22
| DATE | OPPONENT | RESULT | W-L-OTL | Goalie | Top Performer |
| Fri, 15 Oct | W5-1 | 1-0-0 | Anderson | Anderson | |
| Sat, 16 Oct | vs | W2-1 SO | 2-0-0 | Tokarski | Tokarski |
| Wed, 20 Oct | W5-2 | 3-0-0 | Anderson | Anderson | |
| Sat, 23 Oct | L4-1 | 3-1-0 | Anderson | Olofsson | |
| Sun, 24 Oct | L2-1 OT | 3-1-1 | Tokarski | Tokarski | |
| Tue, 26 Oct | W5-1 | 4-1-1 | Anderson | Anderson | |
| Fri, 29 Oct | W4-3 OT | 5-1-1 | Anderson | Asplund | |
| Sun, 31 Oct | L3-2 | 5-2-1 | Tokarski | Olofsson | |
| Wed, 3 Nov | L5-3 | 5-3-1 | Anderson | Skinner | |
| Fri, 5 Nov | L5-2 | 5-4-1 | Tokarski | Cozens | |
| Sat, 6 Nov | L4-3 OT | 5-4-2 | Tokarski | Asplund | |
| Tue, 9 Nov | L5-3 | 5-5-2 | Tokarski | Miller | |
| Sat, 13 Nov | W3-2 | 6-5-2 | Tokarski | Tokarski | |
| Sun, 14 Nov | L5-4 | 6-6-2 | Dell | Skinner | |
| Wed, 17 Nov | W2-1 | 7-6-2 | Tokarski | Tokarski | |
| Fri, 19 Nov | L5-0 | 7-7-2 | Tokarski | Dell | |
| Sun, 21 Nov | L5-4 | 7-8-2 | Dell | Dahlin | |
| Tue, 23 Nov | L7-4 | 7-9-2 | Dell | Thompson | |
| Thu, 25 Nov | L5-1 | 7-10-2 | Dell | Tokarski | |
| Sat, 27 Nov | W4-1 | 8-10-2 | Tokarski | Tokarski | |
| Sun, 28 Nov | L3-2 OT | 8-10-3 | Tokarski | Tokarski | |
| Tue, 30 Nov | L7-4 | 8-11-3 | Tokarski | Murray | |
| Fri, 3 Dec | L7-4 | 8-12-3 | Dell | Hinostroza | |
| Sun, 5 Dec | L6-2 | 8-13-3 | Subban | Olofsson | |
| Wed, 8 Dec | L2-0 | 8-14-3 | Luukkonen | Thompson | |
| Sat, 11 Dec | L2-1 | 8-15-3 | Luukkonen | Luukkonen | |
| Sun, 12 Dec | L3-2 SO | 8-15-4 | Luukkonen | Luukkonen | |
| Wed, 15 Dec | W4-2 | 9-15-4 | Luukkonen | Luukkonen | |
| Fri, 17 Dec | W3-2 SO | 10-15-4 | Luukkonen | Luukkonen | |
| Sat, 18 Dec | L3-2 OT | 10-15-5 | Subban | Subban | |
| Tue, 21 Dec | Postponed | ||||
| Thu, 23 Dec | Postponed | ||||
| Fri, 24 Dec | Postponed | ||||
| Tue, 28 Dec | Postponed | ||||
| Thu, 30 Dec | L4-3 | 10-16-5 | Luukkonen | Thompson | |
| Fri, 31 Dec | L4-1 | 10-17-5 | Subban | Okposo | |
| Sat, 1 Jan | L4-3 OT | 10-17-6 | Luukkonen | Tuch | |
| Fri, 7 Jan | L3-2 | 10-18-6 | Luukkonen | Dahlin | |
| Sun, 9 Jan | Postponed | ||||
| Wed, 12 Jan | L6-1 | 10-19-6 | Luukkonen | Miller | |
| Fri, 14 Jan | W4-1 | 11-19-6 | Dell | Dell | |
| Sun, 16 Jan | L4-0 | 11-20-6 | Dell | Dell | |
| Mon, 17 Jan | L3-2 OT | 11-20-7 | Dell | Skinner | |
| Wed, 19 Jan | W3-1 | 12-20-7 | Houser | Houser | |
| Fri, 21 Jan | L5-4 | 12-21-7 | Dell | Dahlin | |
| Sat, 22 Jan | W6-3 | 13-21-7 | Houser | Krebs | |
| Wed, 26 Jan | L5-0 | 13-22-7 | Dell | Dell | |
| Sun, 30 Jan | @ | W3-1 | 14-22-7 | Anderson | Anderson |
| Mon, 31 Jan | L4-1 | 14-23-7 | Tokarski | Skinner | |
| Wed, 2 Feb | L5-2 | 14-24-7 | Anderson | Hayden | |
| Fri, 11 Feb | L4-3 OT | 14-24-8 | Tokarski | Tuch | |
| Sun, 13 Feb | W5-3 | 15-24-8 | Anderson | Skinner | |
| Wed, 16 Feb | W6-3 | 16-24-8 | Tokarski | Cozens | |
| Fri, 18 Feb | L3-1 | 16-25-8 | Anderson | Anderson | |
| Sat, 19 Feb | L5-3 | 16-26-8 | Tokarski | Thompson | |
| Sun, 20 Feb | L7-3 | 16-27-8 | Anderson | Okposo | |
| Thu, 24 Feb | L4-0 | 16-28-8 | Anderson | Samuelsson | |
| Sat, 26 Feb | L5-3 | 16-29-8 | Tokarski | Cozens | |
| Sun, 27 Feb | L4-2 | 16-30-8 | Anderson | Eakin | |
| Thu, 3 Mar | W5-1 | 17-30-8 | Anderson | Anderson | |
| Sat, 5 Mar | W5-4 | 18-30-8 | Anderson | Skinner | |
| Sun, 6 Mar | L3-0 | 18-31-8 | Tokarski | Tokarski | |
| Tue, 8 Mar | L6-1 | 18-32-8 | Anderson | Hayden | |
| Fri, 11 Mar | W3-1 | 19-32-8 | Anderson | Anderson | |
| Sun, 13 Mar | W5-2 | 20-32-8 | Anderson | Hinostroza | |
| Fri, 18 Mar | L6-1 | 20-33-8 | Anderson | Olofsson | |
| Sat, 19 Mar | W1-0 OT | 21-33-8 | Tokarski | Tokarski | |
| Mon, 21 Mar | W3-2 OT | 22-33-8 | Anderson | Anderson | |
| Wed, 23 Mar | W4-3 SO | 23-33-8 | Anderson | Thompson | |
| Fri, 25 Mar | L4-3 SO | 23-33-9 | Tokarski | Skinner | |
| Sun, 27 Mar | L5-4 OT | 23-33-10 | Anderson | Samuelsson | |
| Tue, 29 Mar | W6-5 | 24-33-10 | Tokarski | Olofsson | |
| Thu, 31 Mar | L3-2 SO | 24-33-11 | Anderson | Girgensons | |
| Sat, 2 Apr | W4-3 | 25-33-11 | Anderson | Thompson | |
| Sun, 3 Apr | L5-3 | 25-34-11 | Tokarski | Okposo | |
| Wed, 6 Apr | W4-2 | 26-34-11 | Anderson | Anderson | |
| Fri, 8 Apr | L5-3 | 26-35-11 | Anderson | Skinner | |
| Sat, 9 Apr | L4-3 | 26-36-11 | Tokarski | Olofsson | |
| Sun, 10 Apr | L5-0 | 26-37-11 | Anderson | Tuch | |
| Wed, 13 Apr | W5-2 | 27-37-11 | Anderson | Dahlin | |
| Fri, 15 Apr | L6-2 | 27-38-11 | Anderson | Asplund | |
| Sun, 17 Apr | W4-3 | 28-38-11 | Anderson | Jokiharju | |
| Sun, 17 Apr | W5-3 | 29-38-11 | Tokarski | Dahlin | |
| Fri, 22 Apr | W5-2 | 30-38-11 | Anderson | Olofsson | |
| Sat, 23 Apr | W5-3 | 31-38-11 | Tokarski | Thompson | |
| Fri, 29 Apr | L5-0 | 31-39-11 | Tokarski | Asplund | |
| Sat, 30 Apr | W3-2 OT | 32-39-11 | Tokarski | Mittelstadt | |