| MLB First Round Draft Picks - San Diego Padres | ||||
| SEASON | PLAYER | POS | SCHOOL/HOMETOWN | PICK |
| 2016 | Eric Lauer | LHP | Kent State | 25 |
| 2016 | Hudson Sanchez | 3B | Southlake (Texas) Carroll High School | 24 |
| 2016 | Cal Quantrill | RHP | Stanford | 8 |
| 2014 | Trea Turner | SS | NC State | 13 |
| 2013 | Hunter Renfroe | RF | Mississippi St. | 13 |
| 2012 | Max Fried | LHP | Harvard-Westlake H.S., Studio City, Calif. | 7 |
| 2011 | Joe Ross | RHP | Bishop O'Dowd High School | 25 |
| 2011 | Cory Spangenberg | 3B | Indian River State College | 10 |
| 2010 | Karsten Whitson | RHP | Chipley (Fla.) HS | 9 |
| 2009 | Donavan Tate | OF | Cartersville (Ga.) HS | 3 |
| 2008 | Allan Dykstra | 1B | Wake Forest | 23 |
| 2007 | Nick Schmidt | LHP | Arkansas | 23 |
| 2006 | Matthew Antonelli | 3B | Wake Forest | 17 |
| 2005 | Cesar Carrillo | RHP | Miami | 18 |
| 2004 | Matt Bush | SS | Mission Bay HS, El Cajon, CA | 1 |
| 2003 | Tim Stauffer | RHP | U. of Richmond | 4 |
| 2002 | Khalil Greene | SS | Clemson | 13 |
| 2001 | Jake Gautreau | 3B | Tulane U | 14 |
| 2000 | Mark Phillips | LHP | Hanover, PA | 9 |
| 1999 | Omar Ortiz | RHP | Texas-Pan Am U. | 29 |
| 1999 | Gerik Baxter | RHP | Edmonds, WA | 28 |
| 1999 | Vince Faison | OF | Lyons, GA | 20 |
| 1998 | Sean Burroughs | 3B | Long Beach, CA | 9 |
| 1997 | Kevin Nicholson | SS | Stetson U | 27 |
| 1996 | Matt Halloran | SS | Fredericksburg, VA | 15 |
| 1995 | Mark Davis | C | Malvern, PA | 2 |
| 1994 | Dustin Hermanson | RHP | Kent State U | 3 |
| 1993 | Derrek Lee | 1B | Granite Bay, CA | 14 |
| 1991 | Johns Hamilton | RHP | Georgia Southern U | 8 |
| 1990 | Robert Beckett | LHP | Austin, TX | 25 |
| 1988 | Andy Benes | RHP | U of Evansville | 1 |
| 1987 | Kevin Garner | RHP-O | U of Texas | 10 |
| 1986 | Thomas Howard | OF | Ball State U | 11 |
| 1985 | Joey Cora | SS | Vanderbilt U | 23 |
| 1984 | Shane Mack | OF | UCLA | 11 |
| 1983 | Ray Hayward | LHP | Oklahoma U | 10 |
| 1982 | Jimmy Jones | RHP | Dallas, TX | 3 |
| 1981 | Frank Castro | C | U of Miami | 26 |
| 1981 | Kevin McReynolds | OF | U of Arkansas | 6 |
| 1980 | Jeff Pyburn | OF | U of Georgia | 5 |
| 1979 | Bob Geren | C | San Diego, CA | 24 |
| 1979 | Joe Lansford | 1B | San Jose, CA | 14 |
| 1978 | Andy Hawkins | RHP | Waco, TX | 5 |
| 1977 | Brian Greer | OF | Brea, CA | 8 |
| 1976 | Bob Owchinko | LHP | Eastern Michigan U | 5 |
| 1975 | Mike Lentz | LHP | Kirkland, WA | 2 |
| 1974 | Bill Almon | SS | Brown U | 1 |
| 1973 | Dave Winfield | OF | U of Minnesota | 4 |
| 1972 | Dave Roberts | 3B | U of Oregon | 1 |
| 1971 | Jay Franklin | RHP | Vienna, VA | 2 |
| 1970 | Mike Ivie | C | Decatur, GA | 1 |
| 1969 | Randy Elliott | 1B | Camarillo, CA | 24 |