| MLB First Round Draft Picks - 1978 | ||||
| PICK | PLAYER | POS | TEAM | SCHOOL/HOMETOWN |
| 1 | Bob Horner | 3B | Atlanta Braves | Arizona State U |
| 2 | Lloyd Moseby | 1B | Toronto Blue Jays | Oakland, CA |
| 3 | Hubie Brooks | SS | New York Mets | Arizona State U |
| 4 | Mike Morgan | RHP | Oakland Athletics | Las Vegas, NV |
| 5 | Andy Hawkins | RHP | San Diego Padres | Waco, TX |
| 6 | Tito Nanni | OF | Seattle Mariners | Philadelphia, PA |
| 7 | Bob Cummings | C | San Francisco Giants | Chicago, IL |
| 8 | Nick Hernandez | C | Milwaukee Brewers | Hialeah, FL |
| 9 | Glenn Franklin | SS | Montreal Expos | Chipola (FL) JC |
| 10 | Phil Lansford | SS | Cleveland Indians | Santa Clara, CA |
| 11 | Rod Boxberger | RHP | Houston Astros | U of Southern California |
| 12 | Kirk Gibson | OF | Detroit Tigers | Michigan State U |
| 13 | Bill Hayes | C | Chicago Cubs | Indiana State U |
| 14 | Tom Brunansky | OF | California Angels | West Covina, CA |
| 15 | Robert Hicks | 1B | St. Louis Cardinals | Pensacola, FL |
| 16 | Lenny Faedo | SS | Minnesota Twins | Tampa, FL |
| 17 | Nick Esasky | SS | Cincinnati Reds | Carol City, FL |
| 18 | Rex Hudler | SS | New York Yankees | Fresno, CA |
| 19 | Brad Garnett | 1B | Pittsburgh Pirates | DeSoto, TX |
| 20 | Tim Conroy | LHP | Oakland Athletics | Monroeville, PA |
| 21 | Gerry Aubin | OF | Pittsburgh Pirates | Albany, GA |
| 22 | Robert Boyce | 3B | Baltimore Orioles | Cincinnati, OH |
| 23 | Rip Rollins | 1B-RH | Philadelphia Phillies | Sparta, NC |
| 24 | Matt Winters | OF | New York Yankees | Williamsville, NY |
| 25 | Buddy Biancalana | SS | Kansas City Royals | Greenbrae, CA |
| 26 | Brian Ryder | RHP | New York Yankees | Shrewsbury, MA |